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Molecular architecture of the glycogen- committed PP1/PTG holoenzyme.
Semrau MS, Giachin G, Covaceuszach S, Cassetta A, Demitri N, Storici P, Lolli G. Semrau MS, et al. Among authors: lolli g. Nat Commun. 2022 Oct 19;13(1):6199. doi: 10.1038/s41467-022-33693-z. Nat Commun. 2022. PMID: 36261419 Free PMC article.
A novel class of selective CK2 inhibitors targeting its open hinge conformation.
Dalle Vedove A, Zonta F, Zanforlin E, Demitri N, Ribaudo G, Cazzanelli G, Ongaro A, Sarno S, Zagotto G, Battistutta R, Ruzzene M, Lolli G. Dalle Vedove A, et al. Among authors: lolli g. Eur J Med Chem. 2020 Jun 1;195:112267. doi: 10.1016/j.ejmech.2020.112267. Epub 2020 Mar 25. Eur J Med Chem. 2020. PMID: 32283296
Pharmacological inactivation of the prion protein by targeting a folding intermediate.
Spagnolli G, Massignan T, Astolfi A, Biggi S, Rigoli M, Brunelli P, Libergoli M, Ianeselli A, Orioli S, Boldrini A, Terruzzi L, Bonaldo V, Maietta G, Lorenzo NL, Fernandez LC, Codeseira YB, Tosatto L, Linsenmeier L, Vignoli B, Petris G, Gasparotto D, Pennuto M, Guella G, Canossa M, Altmeppen HC, Lolli G, Biressi S, Pastor MM, Requena JR, Mancini I, Barreca ML, Faccioli P, Biasini E. Spagnolli G, et al. Among authors: lolli g. Commun Biol. 2021 Jan 12;4(1):62. doi: 10.1038/s42003-020-01585-x. Commun Biol. 2021. PMID: 33437023 Free PMC article.
Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing.
Dalle Vedove A, Cazzanelli G, Batiste L, Marchand JR, Spiliotopoulos D, Corsi J, D'Agostino VG, Caflisch A, Lolli G. Dalle Vedove A, et al. Among authors: lolli g. ACS Med Chem Lett. 2022 Aug 3;13(9):1434-1443. doi: 10.1021/acsmedchemlett.2c00173. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105334 Free PMC article.
Discovery of BAZ2A bromodomain ligands.
Spiliotopoulos D, Wamhoff EC, Lolli G, Rademacher C, Caflisch A. Spiliotopoulos D, et al. Among authors: lolli g. Eur J Med Chem. 2017 Oct 20;139:564-572. doi: 10.1016/j.ejmech.2017.08.028. Epub 2017 Aug 12. Eur J Med Chem. 2017. PMID: 28837921
191 results