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Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual.
Guerra D, Beaumont T, RadiÄ L, Kerster G, van der Straten K, Yuan M, Torres JL, Lee WH, Liu H, Poniman M, Bontjer I, Burger JA, Claireaux M, Caniels TG, Snitselaar JL, Bijl TPL, Kruijer S, Ozorowski G, Gideonse D, Sliepen K, Ward AB, Eggink D, de Bree GJ, Wilson IA, Sanders RW, van Gils MJ. Guerra D, et al. Among authors: bontjer i. bioRxiv [Preprint]. 2022 Oct 14:2022.10.14.512216. doi: 10.1101/2022.10.14.512216. bioRxiv. 2022. Update in: iScience. 2023 Sep 22;26(10):108009. doi: 10.1016/j.isci.2023.108009 PMID: 36263063 Free PMC article. Updated. Preprint.
Stabilized HIV-1 envelope glycoprotein trimers lacking the V1V2 domain, obtained by virus evolution.
Bontjer I, Melchers M, Eggink D, David K, Moore JP, Berkhout B, Sanders RW. Bontjer I, et al. J Biol Chem. 2010 Nov 19;285(47):36456-70. doi: 10.1074/jbc.M110.156588. Epub 2010 Sep 8. J Biol Chem. 2010. PMID: 20826824 Free PMC article.
The design of the trimers was guided by HIV-1 evolution studies that identified compensatory changes in V1V2-deleted but functional Env proteins (Bontjer, I., Land, A., Eggink, D., Verkade, E., Tuin, K., Baldwin, C., Pollakis, G., Paxton, W. A., Braakman, I., …
The design of the trimers was guided by HIV-1 evolution studies that identified compensatory changes in V1V2-deleted but functional Env prot …
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.
de Taeye SW, Ozorowski G, Torrents de la Peña A, Guttman M, Julien JP, van den Kerkhof TL, Burger JA, Pritchard LK, Pugach P, Yasmeen A, Crampton J, Hu J, Bontjer I, Torres JL, Arendt H, DeStefano J, Koff WC, Schuitemaker H, Eggink D, Berkhout B, Dean H, LaBranche C, Crotty S, Crispin M, Montefiori DC, Klasse PJ, Lee KK, Moore JP, Wilson IA, Ward AB, Sanders RW. de Taeye SW, et al. Among authors: bontjer i. Cell. 2015 Dec 17;163(7):1702-15. doi: 10.1016/j.cell.2015.11.056. Cell. 2015. PMID: 26687358 Free PMC article.
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.
Sliepen K, Han BW, Bontjer I, Mooij P, Garces F, Behrens AJ, Rantalainen K, Kumar S, Sarkar A, Brouwer PJM, Hua Y, Tolazzi M, Schermer E, Torres JL, Ozorowski G, van der Woude P, de la Peña AT, van Breemen MJ, Camacho-Sánchez JM, Burger JA, Medina-Ramírez M, González N, Alcami J, LaBranche C, Scarlatti G, van Gils MJ, Crispin M, Montefiori DC, Ward AB, Koopman G, Moore JP, Shattock RJ, Bogers WM, Wilson IA, Sanders RW. Sliepen K, et al. Among authors: bontjer i. Nat Commun. 2019 May 29;10(1):2355. doi: 10.1038/s41467-019-10262-5. Nat Commun. 2019. PMID: 31142746 Free PMC article.
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