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Page 1
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.
Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI. Jenster LM, et al. Among authors: geyer m. J Exp Med. 2023 Jan 2;220(1):e20220837. doi: 10.1084/jem.20220837. Epub 2022 Oct 31. J Exp Med. 2023. PMID: 36315050 Free PMC article.
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease.
Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Venegas C, et al. Among authors: geyer m. Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158. Nature. 2017. PMID: 29293211
Alternative splicing regulates stochastic NLRP3 activity.
Hoss F, Mueller JL, Rojas Ringeling F, Rodriguez-Alcazar JF, Brinkschulte R, Seifert G, Stahl R, Broderick L, Putnam CD, Kolodner RD, Canzar S, Geyer M, Hoffman HM, Latz E. Hoss F, et al. Among authors: geyer m. Nat Commun. 2019 Jul 19;10(1):3238. doi: 10.1038/s41467-019-11076-1. Nat Commun. 2019. PMID: 31324763 Free PMC article.
β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.
Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT. Friker LL, et al. Among authors: geyer m. Cell Rep. 2020 Mar 17;30(11):3743-3754.e6. doi: 10.1016/j.celrep.2020.02.025. Cell Rep. 2020. PMID: 32187546 Free PMC article.
Rational discovery of molecular glue degraders via scalable chemical profiling.
Mayor-Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichova H, Kaltheuner IH, Hahn E, Seiler K, Koren A, Petzold G, Fellner M, Bock C, Müller AC, Zuber J, Geyer M, Thomä NH, Kubicek S, Winter GE. Mayor-Ruiz C, et al. Among authors: geyer m. Nat Chem Biol. 2020 Nov;16(11):1199-1207. doi: 10.1038/s41589-020-0594-x. Epub 2020 Aug 3. Nat Chem Biol. 2020. PMID: 32747809 Free PMC article.
NLRP1 variant M1184V decreases inflammasome activation in the context of DPP9 inhibition and asthma severity.
Moecking J, Laohamonthonkul P, Chalker K, White MJ, Harapas CR, Yu CH, Davidson S, Hrovat-Schaale K, Hu D, Eng C, Huntsman S, Calleja DJ, Horvat JC, Hansbro PM, O'Donoghue RJJ, Ting JP, Burchard EG, Geyer M, Gerlic M, Masters SL. Moecking J, et al. Among authors: geyer m. J Allergy Clin Immunol. 2021 Jun;147(6):2134-2145.e20. doi: 10.1016/j.jaci.2020.12.636. Epub 2020 Dec 27. J Allergy Clin Immunol. 2021. PMID: 33378691 Free PMC article.
1,111 results