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A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy.
Quijano-Rubio A, Bhuiyan AM, Yang H, Leung I, Bello E, Ali LR, Zhangxu K, Perkins J, Chun JH, Wang W, Lajoie MJ, Ravichandran R, Kuo YH, Dougan SK, Riddell SR, Spangler JB, Dougan M, Silva DA, Baker D. Quijano-Rubio A, et al. Among authors: chun jh. Nat Biotechnol. 2023 Apr;41(4):532-540. doi: 10.1038/s41587-022-01510-z. Epub 2022 Oct 31. Nat Biotechnol. 2023. PMID: 36316485 Free PMC article.
Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.
Yang H, Ulge UY, Quijano-Rubio A, Bernstein ZJ, Maestas DR, Chun JH, Wang W, Lin JX, Jude KM, Singh S, Orcutt-Jahns BT, Li P, Mou J, Chung L, Kuo YH, Ali YH, Meyer AS, Grayson WL, Heller NM, Garcia KC, Leonard WJ, Silva DA, Elisseeff JH, Baker D, Spangler JB. Yang H, et al. Among authors: chun jh. Nat Chem Biol. 2023 Sep;19(9):1127-1137. doi: 10.1038/s41589-023-01313-6. Epub 2023 Apr 6. Nat Chem Biol. 2023. PMID: 37024727 Free PMC article.
Potent antitumor activity of a designed interleukin-21 mimic.
Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, Palin CA, Khanna A, Tower S, Kureshi R, Hoffman MT, Sharova T, Lawless A, Cohen S, Boland GM, Nguyen T, Peprah F, Tello JG, Liu SY, Kim CJ, Shin H, Quijano-Rubio A, Jude KM, Gerben S, Murray A, Heine P, DeWitt M, Ulge UY, Carter L, King NP, Silva DA, Kueh HY, Kalia V, Sarkar S, Jenkins RW, Garcia KC, Leonard WJ, Dougan M, Dougan SK, Baker D. Chun JH, et al. bioRxiv [Preprint]. 2024 Dec 7:2024.12.06.626481. doi: 10.1101/2024.12.06.626481. bioRxiv. 2024. PMID: 39677740 Free PMC article. Preprint.
Scaffolding protein functional sites using deep learning.
Wang J, Lisanza S, Juergens D, Tischer D, Watson JL, Castro KM, Ragotte R, Saragovi A, Milles LF, Baek M, Anishchenko I, Yang W, Hicks DR, Expòsit M, Schlichthaerle T, Chun JH, Dauparas J, Bennett N, Wicky BIM, Muenks A, DiMaio F, Correia B, Ovchinnikov S, Baker D. Wang J, et al. Among authors: chun jh. Science. 2022 Jul 22;377(6604):387-394. doi: 10.1126/science.abn2100. Epub 2022 Jul 21. Science. 2022. PMID: 35862514 Free PMC article.
Computational design of bifaceted protein nanomaterials with tailorable properties.
Rankovic S, Carr KD, Decarreau J, Skotheim R, Kibler RD, Ols S, Lee S, Chun J, Tooley M, Dauparas J, Eisenach HE, Glögl M, Weidle C, Borst AJ, Baker D, King NP. Rankovic S, et al. bioRxiv [Preprint]. 2024 Oct 22:2024.10.18.619149. doi: 10.1101/2024.10.18.619149. bioRxiv. 2024. PMID: 39484564 Free PMC article. Preprint.
192 results