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SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir.
Mesci P, de Souza JS, Martin-Sancho L, Macia A, Saleh A, Yin X, Snethlage C, Adams JW, Avansini SH, Herai RH, Almenar-Queralt A, Pu Y, Szeto RA, Goldberg G, Bruck PT, Papes F, Chanda SK, Muotri AR. Mesci P, et al. Among authors: muotri ar. PLoS Biol. 2022 Nov 3;20(11):e3001845. doi: 10.1371/journal.pbio.3001845. eCollection 2022 Nov. PLoS Biol. 2022. PMID: 36327326 Free PMC article.
Stem cells and modeling of autism spectrum disorders.
Freitas BC, Trujillo CA, Carromeu C, Yusupova M, Herai RH, Muotri AR. Freitas BC, et al. Among authors: muotri ar. Exp Neurol. 2014 Oct;260:33-43. doi: 10.1016/j.expneurol.2012.09.017. Epub 2012 Oct 2. Exp Neurol. 2014. PMID: 23036599 Free PMC article. Review.
Differential L1 regulation in pluripotent stem cells of humans and apes.
Marchetto MCN, Narvaiza I, Denli AM, Benner C, Lazzarini TA, Nathanson JL, Paquola ACM, Desai KN, Herai RH, Weitzman MD, Yeo GW, Muotri AR, Gage FH. Marchetto MCN, et al. Among authors: muotri ar. Nature. 2013 Nov 28;503(7477):525-529. doi: 10.1038/nature12686. Epub 2013 Oct 23. Nature. 2013. PMID: 24153179 Free PMC article.
Altered neuronal network and rescue in a human MECP2 duplication model.
Nageshappa S, Carromeu C, Trujillo CA, Mesci P, Espuny-Camacho I, Pasciuto E, Vanderhaeghen P, Verfaillie CM, Raitano S, Kumar A, Carvalho CM, Bagni C, Ramocki MB, Araujo BH, Torres LB, Lupski JR, Van Esch H, Muotri AR. Nageshappa S, et al. Among authors: muotri ar. Mol Psychiatry. 2016 Feb;21(2):178-88. doi: 10.1038/mp.2015.128. Epub 2015 Sep 8. Mol Psychiatry. 2016. PMID: 26347316 Free PMC article.
Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction.
Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A. Zhang ZN, et al. Among authors: muotri ar. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3185-90. doi: 10.1073/pnas.1521255113. Epub 2016 Mar 4. Proc Natl Acad Sci U S A. 2016. PMID: 26944080 Free PMC article.
IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3.
de Souza JS, Carromeu C, Torres LB, Araujo BH, Cugola FR, Maciel RM, Muotri AR, Giannocco G. de Souza JS, et al. Among authors: muotri ar. Hum Mol Genet. 2017 Jan 15;26(2):270-281. doi: 10.1093/hmg/ddw384. Hum Mol Genet. 2017. PMID: 28007906 Free PMC article.
202 results