Keane P - Search Results

1

Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia.

Adamo A, Chin P, Keane P, Assi SA, Potluri S, Kellaway SG, Coleman D, Ames L, Ptasinska A, Delwel HR, Cockerill PN, Bonifer C. Adamo A, et al. Among authors: keane p. Leukemia. 2023 Jan;37(1):102-112. doi: 10.1038/s41375-022-01744-5. Epub 2022 Nov 4. Leukemia. 2023. PMID: 36333583 Free PMC article.

2

C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia.

Loke J, Chin PS, Keane P, Pickin A, Assi SA, Ptasinska A, Imperato MR, Cockerill PN, Bonifer C. Loke J, et al. Among authors: keane p. Blood Adv. 2018 Feb 13;2(3):271-284. doi: 10.1182/bloodadvances.2017012781. Blood Adv. 2018. PMID: 29431622 Free PMC article.

3

Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones.

de Boer B, Prick J, Pruis MG, Keane P, Imperato MR, Jaques J, Brouwers-Vos AZ, Hogeling SM, Woolthuis CM, Nijk MT, Diepstra A, Wandinger S, Versele M, Attar RM, Cockerill PN, Huls G, Vellenga E, Mulder AB, Bonifer C, Schuringa JJ. de Boer B, et al. Among authors: keane p. Cancer Cell. 2018 Oct 8;34(4):674-689.e8. doi: 10.1016/j.ccell.2018.08.014. Epub 2018 Sep 20. Cancer Cell. 2018. PMID: 30245083 Free article.

4

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.

Gilmour J, O'Connor L, Middleton CP, Keane P, Gillemans N, Cazier JB, Philipsen S, Bonifer C. Gilmour J, et al. Among authors: keane p. Epigenetics Chromatin. 2019 Jun 4;12(1):33. doi: 10.1186/s13072-019-0282-9. Epigenetics Chromatin. 2019. PMID: 31164147 Free PMC article.

5

RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks.

Kellaway SG, Keane P, Kennett E, Bonifer C. Kellaway SG, et al. Among authors: keane p. Haematologica. 2021 Jun 1;106(6):1569-1580. doi: 10.3324/haematol.2019.241885. Haematologica. 2021. PMID: 32299907 Free PMC article.

6

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells.

Nafria M, Keane P, Ng ES, Stanley EG, Elefanty AG, Bonifer C. Nafria M, et al. Among authors: keane p. Cell Rep. 2020 May 26;31(8):107691. doi: 10.1016/j.celrep.2020.107691. Cell Rep. 2020. PMID: 32460028 Free PMC article.

7

Chromatin Priming Renders T Cell Tolerance-Associated Genes Sensitive to Activation below the Signaling Threshold for Immune Response Genes.

Bevington SL, Ng STH, Britton GJ, Keane P, Wraith DC, Cockerill PN. Bevington SL, et al. Among authors: keane p. Cell Rep. 2020 Jun 9;31(10):107748. doi: 10.1016/j.celrep.2020.107748. Cell Rep. 2020. PMID: 32521273 Free PMC article.

8

IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors.

Bevington SL, Keane P, Soley JK, Tauch S, Gajdasik DW, Fiancette R, Matei-Rascu V, Willis CM, Withers DR, Cockerill PN. Bevington SL, et al. Among authors: keane p. EMBO J. 2020 Nov 16;39(22):e105220. doi: 10.15252/embj.2020105220. Epub 2020 Sep 15. EMBO J. 2020. PMID: 32930455 Free PMC article.

9

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories.

Kellaway SG, Keane P, Edginton-White B, Regha K, Kennett E, Bonifer C. Kellaway SG, et al. Among authors: keane p. Life Sci Alliance. 2021 Jan 4;4(2):e202000864. doi: 10.26508/lsa.202000864. Print 2021 Feb. Life Sci Alliance. 2021. PMID: 33397648 Free PMC article.

10

Stable Epigenetic Programming of Effector and Central Memory CD4 T Cells Occurs Within 7 Days of Antigen Exposure In Vivo.

Bevington SL, Fiancette R, Gajdasik DW, Keane P, Soley JK, Willis CM, Coleman DJL, Withers DR, Cockerill PN. Bevington SL, et al. Among authors: keane p. Front Immunol. 2021 May 24;12:642807. doi: 10.3389/fimmu.2021.642807. eCollection 2021. Front Immunol. 2021. PMID: 34108962 Free PMC article.

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