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Page 1
GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.
Senkevich K, Zorca CE, Dworkind A, Rudakou U, Somerville E, Yu E, Ermolaev A, Nikanorova D, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Grenn FP, Chiang MSR, Sardi SP, Vanderperre B, Blauwendraat C, Trempe JF, Fon EA, Durcan TM, Alcalay RN, Gan-Or Z. Senkevich K, et al. Among authors: zorca ce. Brain. 2023 May 2;146(5):1859-1872. doi: 10.1093/brain/awac413. Brain. 2023. PMID: 36370000 Free PMC article.
Rapid macropinocytic transfer of α-synuclein to lysosomes.
Bayati A, Banks E, Han C, Luo W, Reintsch WE, Zorca CE, Shlaifer I, Del Cid Pellitero E, Vanderperre B, McBride HM, Fon EA, Durcan TM, McPherson PS. Bayati A, et al. Among authors: zorca ce. Cell Rep. 2022 Jul 19;40(3):111102. doi: 10.1016/j.celrep.2022.111102. Cell Rep. 2022. PMID: 35858558 Free article.
Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress.
Eldeeb MA, Bayne AN, Fallahi A, Goiran T, MacDougall EJ, Soumbasis A, Zorca CE, Jones-Tabah J, Thomas RA, Karpilovsky N, Mathur M, Durcan TM, Trempe JF, Fon EA. Eldeeb MA, et al. Among authors: zorca ce. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2313540121. doi: 10.1073/pnas.2313540121. Epub 2024 Feb 28. Proc Natl Acad Sci U S A. 2024. PMID: 38416681 Free PMC article.
Modeling Parkinson's disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines.
Bayati A, Ayoubi R, Aguila A, Zorca CE, Deyab G, Han C, Recinto SJ, Nguyen-Renou E, Rocha C, Maussion G, Luo W, Shlaifer I, Banks E, McDowell I, Del Cid Pellitero E, Ding XE, Sharif B, Séguéla P, Yaqubi M, Chen CX, You Z, Abdian N, McBride HM, Fon EA, Stratton JA, Durcan TM, Nahirney PC, McPherson PS. Bayati A, et al. Among authors: zorca ce. Nat Neurosci. 2024 Dec;27(12):2401-2416. doi: 10.1038/s41593-024-01775-4. Epub 2024 Oct 8. Nat Neurosci. 2024. PMID: 39379564
Targeting Cancer Cells via N-degron-based PROTACs.
Eldeeb MA, Zorca CE, Fahlman RP. Eldeeb MA, et al. Among authors: zorca ce. Endocrinology. 2020 Dec 1;161(12):bqaa185. doi: 10.1210/endocr/bqaa185. Endocrinology. 2020. PMID: 33159513
17 results