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Design, synthesis and biological evaluation of novel pyrazolo-pyrimidin-amines as potent and selective BTK inhibitors.
Joshi D, Bahekar R, Soman S, Jadav P, Patel D, Goswami A, Pethani J, Kumar J, Patel J, Sundar R, Goswami P, Goshdastidar K, Patel H, Patel A, Bandyopadhyay D, Chattarjee A, Sharma M, Jain M, Desai R. Joshi D, et al. Among authors: kumar j. Bioorg Chem. 2023 Jan;130:106238. doi: 10.1016/j.bioorg.2022.106238. Epub 2022 Nov 14. Bioorg Chem. 2023. PMID: 36403335
Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors.
Bahekar R, Dave B, Soman S, Patel D, Chopade R, Funde R, Kumar J, Sachchidanand S, Giri P, Chatterjee A, Mahapatra J, Vyas P, Ghoshdastidar K, Bandyopadhyay D, Desai RC. Bahekar R, et al. Among authors: kumar j. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1313-1319. doi: 10.1016/j.bmcl.2019.04.007. Epub 2019 Apr 4. Bioorg Med Chem Lett. 2019. PMID: 30975623
Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors.
Bahekar R, Panchal N, Soman S, Desai J, Patel D, Argade A, Gite A, Gite S, Patel B, Kumar J, S S, Patel H, Sundar R, Chatterjee A, Mahapatra J, Patel H, Ghoshdastidar K, Bandyopadhyay D, Desai RC. Bahekar R, et al. Among authors: kumar j. Bioorg Chem. 2020 Jun;99:103851. doi: 10.1016/j.bioorg.2020.103851. Epub 2020 Apr 18. Bioorg Chem. 2020. PMID: 32334196
Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor.
Desai J, Patel B, Gite A, Panchal N, Gite S, Argade A, Kumar J, Sachchidanand S, Bandyopadhyay D, Ghoshdastidar K, Patel H, Chatterjee A, Mahapatra J, Sharma M, Giri P, Kumar S, Jain M, Sharma R, Desai R. Desai J, et al. Among authors: kumar j, kumar s. Bioorg Med Chem Lett. 2022 Jun 15;66:128728. doi: 10.1016/j.bmcl.2022.128728. Epub 2022 Apr 9. Bioorg Med Chem Lett. 2022. PMID: 35413417
Synthesis and structure-activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: application of weakly basic sulfoximine group as novel S4 binding element.
Pandya V, Jain M, Chakrabarti G, Soni H, Parmar B, Chaugule B, Patel J, Jarag T, Joshi J, Joshi N, Rath A, Unadkat V, Sharma B, Ajani H, Kumar J, Sairam KV, Patel H, Patel P. Pandya V, et al. Among authors: kumar j. Eur J Med Chem. 2012 Dec;58:136-52. doi: 10.1016/j.ejmech.2012.10.005. Epub 2012 Oct 16. Eur J Med Chem. 2012. PMID: 23124211
Biomarkers.
Damuka N, Gollepalli KK, Krizan I, Bhoopal B, Miller M, Deep O, Bashetti N, Kumar JS, Orr ME, Macauley SL, Whitlow CT, Mintz A, Lockhart SN, Craft S, Sai KKS. Damuka N, et al. Among authors: kumar js. Alzheimers Dement. 2024 Dec;20 Suppl 2:e090993. doi: 10.1002/alz.090993. Alzheimers Dement. 2024. PMID: 39785349
Biomarkers.
Gollepalli KK, Bhoopal B, Damuka N, Krizan I, Miller M, Kumar JS, Bashetti N, Whitlow CT, Lockhart SN, Jadiya P, Sai KKS. Gollepalli KK, et al. Among authors: kumar js. Alzheimers Dement. 2024 Dec;20 Suppl 2:e089711. doi: 10.1002/alz.089711. Alzheimers Dement. 2024. PMID: 39784208
Alzheimer's Imaging Consortium.
Damuka N, Gollepalli KK, Krizan I, Bhoopal B, Miller M, Deep O, Bashetti N, Kumar JS, Orr ME, Macauley SL, Whitlow CT, Mintz A, Lockhart SN, Craft S, Sai KKS. Damuka N, et al. Among authors: kumar js. Alzheimers Dement. 2024 Dec;20 Suppl 9:e093929. doi: 10.1002/alz.093929. Alzheimers Dement. 2024. PMID: 39782984
2,764 results