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The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune response.
Senent Y, Remírez A, Repáraz D, Llopiz D, Celias DP, Sainz C, Entrialgo-Cadierno R, Suarez L, Rouzaut A, Alignani D, Tavira B, Lambris JD, Woodruff TM, de Andrea CE, Ruffell B, Sarobe P, Ajona D, Pio R. Senent Y, et al. Among authors: reparaz d. Cancer Immunol Res. 2024 Dec 12. doi: 10.1158/2326-6066.CIR-24-0250. Online ahead of print. Cancer Immunol Res. 2024. PMID: 39666368
Human T cells engineered with an HLA-A2-restricted murine T-cell receptor targeting Glypican 3 effectively control human hepatocellular carcinoma in mice.
Vercher E, Covo-Vergara Á, Conde E, Hernández-Rueda M, Elizalde E, Mancheño U, Glez-Vaz J, Tamayo-Uria I, García-García MR, Ferrer-Roig M, Marañón-Lopez J, Repáraz D, Ruiz M, López-Díaz de Cerio A, Inogés S, Iñarrairaegui M, Lasarte JJ, Sangro B, Sarobe P, Hervas-Stubbs S. Vercher E, et al. Among authors: reparaz d. Hepatology. 2024 Nov 26. doi: 10.1097/HEP.0000000000001175. Online ahead of print. Hepatology. 2024. PMID: 39601444
Identification of HLA class I-restricted immunogenic neoantigens in triple negative breast cancer.
Aparicio B, Repáraz D, Ruiz M, Llopiz D, Silva L, Vercher E, Theunissen P, Tamayo I, Smerdou C, Igea A, Santisteban M, Gónzalez-Deza C, Lasarte JJ, Hervás-Stubbs S, Sarobe P. Aparicio B, et al. Among authors: reparaz d. Front Immunol. 2022 Nov 2;13:985886. doi: 10.3389/fimmu.2022.985886. eCollection 2022. Front Immunol. 2022. PMID: 36405725 Free PMC article.
Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy.
Navarro F, Casares N, Martín-Otal C, Lasarte-Cía A, Gorraiz M, Sarrión P, Llopiz D, Reparaz D, Varo N, Rodriguez-Madoz JR, Prosper F, Hervás-Stubbs S, Lozano T, Lasarte JJ. Navarro F, et al. Among authors: reparaz d. Oncoimmunology. 2022 May 1;11(1):2070337. doi: 10.1080/2162402X.2022.2070337. eCollection 2022. Oncoimmunology. 2022. PMID: 35529677 Free PMC article.
14 results