Kang D - Search Results

1

Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs.

Sun Y, Zhou Z, Feng D, Jing L, Zhao F, Wang Z, Zhang T, Lin H, Song H, De Clercq E, Pannecouque C, Zhan P, Liu X, Kang D. Sun Y, et al. Among authors: kang d. J Med Chem. 2022 Dec 8;65(23):15608-15626. doi: 10.1021/acs.jmedchem.2c00576. Epub 2022 Nov 21. J Med Chem. 2022. PMID: 36411036

2

"Old friends in new guise": exploiting privileged structures for scaffold re-evolution/refining.

Song Y, Chen W, Kang D, Zhang Q, Zhan P, Liu X. Song Y, et al. Among authors: kang d. Comb Chem High Throughput Screen. 2014;17(6):536-53. doi: 10.2174/1386207317666140122101631. Comb Chem High Throughput Screen. 2014. PMID: 24446784 Review.

3

"Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.

Kang D, Song Y, Chen W, Zhan P, Liu X. Kang D, et al. Mol Biosyst. 2014 Aug;10(8):1998-2022. doi: 10.1039/c4mb00147h. Mol Biosyst. 2014. PMID: 24841339 Review.

4

Discovery and characterization of novel imidazopyridine derivative CHEQ-2 as a potent CDC25 inhibitor and promising anticancer drug candidate.

Song Y, Lin X, Kang D, Li X, Zhan P, Liu X, Zhang Q. Song Y, et al. Among authors: kang d. Eur J Med Chem. 2014 Jul 23;82:293-307. doi: 10.1016/j.ejmech.2014.05.063. Epub 2014 May 27. Eur J Med Chem. 2014. PMID: 24922544

5

Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections.

Kang D, Fang Z, Huang B, Zhang L, Liu H, Pannecouque C, Naesens L, De Clercq E, Zhan P, Liu X. Kang D, et al. Chem Biol Drug Des. 2015 Oct;86(4):568-77. doi: 10.1111/cbdd.12520. Epub 2015 Feb 6. Chem Biol Drug Des. 2015. PMID: 25600073

6

Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors.

Fang Z, Kang D, Zhang L, Huang B, Liu H, Pannecouque C, De Clercq E, Zhan P, Liu X. Fang Z, et al. Among authors: kang d. Chem Biol Drug Des. 2015 Oct;86(4):614-8. doi: 10.1111/cbdd.12524. Epub 2015 Feb 19. Chem Biol Drug Des. 2015. PMID: 25626467

7

Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities.

Huang B, Kang D, Zhan P, Liu X. Huang B, et al. Among authors: kang d. Expert Opin Drug Discov. 2015 Dec;10(12):1271-81. doi: 10.1517/17460441.2015.1083007. Epub 2015 Sep 15. Expert Opin Drug Discov. 2015. PMID: 26372893 Review.

8

Novel diarylpyrimidines and diaryltriazines as potent HIV-1 NNRTIs with dramatically improved solubility: a patent evaluation of US20140378443A1.

Huang B, Kang D, Yang J, Zhan P, Liu X. Huang B, et al. Among authors: kang d. Expert Opin Ther Pat. 2016;26(2):281-9. doi: 10.1517/13543776.2016.1113256. Epub 2015 Nov 11. Expert Opin Ther Pat. 2016. PMID: 26559996 Review.

9

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket.

Yang J, Chen W, Kang D, Lu X, Li X, Liu Z, Huang B, Daelemans D, Pannecouque C, De Clercq E, Zhan P, Liu X. Yang J, et al. Among authors: kang d. Eur J Med Chem. 2016 Feb 15;109:294-304. doi: 10.1016/j.ejmech.2015.11.039. Epub 2015 Dec 22. Eur J Med Chem. 2016. PMID: 26802545

10

Discovery of non-peptide small molecular CXCR4 antagonists as anti-HIV agents: Recent advances and future opportunities.

Zhang H, Kang D, Huang B, Liu N, Zhao F, Zhan P, Liu X. Zhang H, et al. Among authors: kang d. Eur J Med Chem. 2016 May 23;114:65-78. doi: 10.1016/j.ejmech.2016.02.051. Epub 2016 Feb 24. Eur J Med Chem. 2016. PMID: 26974376 Review.

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