Wang Z - Search Results

1

Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs.

Sun Y, Zhou Z, Feng D, Jing L, Zhao F, Wang Z, Zhang T, Lin H, Song H, De Clercq E, Pannecouque C, Zhan P, Liu X, Kang D. Sun Y, et al. Among authors: wang z. J Med Chem. 2022 Dec 8;65(23):15608-15626. doi: 10.1021/acs.jmedchem.2c00576. Epub 2022 Nov 21. J Med Chem. 2022. PMID: 36411036

2

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

Kang D, Ding X, Wu G, Huo Z, Zhou Z, Zhao T, Feng D, Wang Z, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Kang D, et al. Among authors: wang z. ACS Med Chem Lett. 2017 Oct 19;8(11):1188-1193. doi: 10.1021/acsmedchemlett.7b00361. eCollection 2017 Nov 9. ACS Med Chem Lett. 2017. PMID: 29152052 Free PMC article.

3

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.

Huo Z, Zhang H, Kang D, Zhou Z, Wu G, Desta S, Zuo X, Wang Z, Jing L, Ding X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Huo Z, et al. Among authors: wang z. ACS Med Chem Lett. 2018 Feb 27;9(4):334-338. doi: 10.1021/acsmedchemlett.7b00524. eCollection 2018 Apr 12. ACS Med Chem Lett. 2018. PMID: 29670696 Free PMC article.

4

Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.

Kang D, Wang Z, Zhang H, Wu G, Zhao T, Zhou Z, Huo Z, Huang B, Feng D, Ding X, Zhang J, Zuo X, Jing L, Luo W, Guma S, Daelemans D, Clercq E, Pannecouque C, Zhan P, Liu X. Kang D, et al. Among authors: wang z. ACS Med Chem Lett. 2018 Mar 1;9(4):370-375. doi: 10.1021/acsmedchemlett.8b00054. eCollection 2018 Apr 12. ACS Med Chem Lett. 2018. PMID: 29670703 Free PMC article.

5

Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.

Wang Z, Kang D, Chen M, Wu G, Feng D, Zhao T, Zhou Z, Huo Z, Jing L, Zuo X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Wang Z, et al. Chem Biol Drug Des. 2018 Dec;92(6):2009-2021. doi: 10.1111/cbdd.13373. Epub 2018 Aug 26. Chem Biol Drug Des. 2018. PMID: 30079476

6

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I.

Kang D, Wang Z, Chen M, Feng D, Wu G, Zhou Z, Jing L, Zuo X, Jiang X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Kang D, et al. Among authors: wang z. Chem Biol Drug Des. 2019 Apr;93(4):430-437. doi: 10.1111/cbdd.13429. Epub 2019 Feb 22. Chem Biol Drug Des. 2019. PMID: 30381875

7

Development of a practical synthesis of etravirine via a microwave-promoted amination.

Feng D, Wei F, Wang Z, Kang D, Zhan P, Liu X. Feng D, et al. Among authors: wang z. Chem Cent J. 2018 Dec 20;12(1):144. doi: 10.1186/s13065-018-0504-4. Chem Cent J. 2018. PMID: 30569261 Free PMC article.

8

Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.

Feng D, Lin H, Jiang L, Wang Z, Sun Y, Zhou Z, Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Feng D, et al. Among authors: wang z. Molecules. 2022 Nov 3;27(21):7538. doi: 10.3390/molecules27217538. Molecules. 2022. PMID: 36364360 Free PMC article.

9

Structure-Based Discovery and Characterization of a Preclinical Drug Candidate for the Treatment of HIV-1 Infection.

Kang D, Yang J, Kong L, Luo R, Huang X, Zhang T, Ma M, Feng D, Wang Z, Fang H, Zhan P, Zheng Y, Liu X. Kang D, et al. Among authors: wang z. Viruses. 2022 Oct 28;14(11):2390. doi: 10.3390/v14112390. Viruses. 2022. PMID: 36366488 Free PMC article.

10

Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation.

Feng D, Lin H, Jiang L, Dai J, Zhang X, Zhou Z, Sun Y, Wang Z, Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Feng D, et al. Among authors: wang z. Eur J Med Chem. 2023 Jan 15;246:114957. doi: 10.1016/j.ejmech.2022.114957. Epub 2022 Nov 22. Eur J Med Chem. 2023. PMID: 36446205

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