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HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Sargsyan A, Doridot L, Hannou SA, Tong W, Srinivasan H, Ivison R, Monn R, Kou HH, Haldeman JM, Arlotto M, White PJ, Grimsrud PA, Astapova I, Tsai LT, Herman MA. Sargsyan A, et al. Among authors: herman ma. JCI Insight. 2023 Jan 10;8(1):e153740. doi: 10.1172/jci.insight.153740. JCI Insight. 2023. PMID: 36413406 Free PMC article.
A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism.
Fisher FM, Kim M, Doridot L, Cunniff JC, Parker TS, Levine DM, Hellerstein MK, Hudgins LC, Maratos-Flier E, Herman MA. Fisher FM, et al. Among authors: herman ma. Mol Metab. 2016 Nov 23;6(1):14-21. doi: 10.1016/j.molmet.2016.11.008. eCollection 2017 Jan. Mol Metab. 2016. PMID: 28123933 Free PMC article.
Intestinal, but not hepatic, ChREBP is required for fructose tolerance.
Kim M, Astapova II, Flier SN, Hannou SA, Doridot L, Sargsyan A, Kou HH, Fowler AJ, Liang G, Herman MA. Kim M, et al. Among authors: herman ma. JCI Insight. 2017 Dec 21;2(24):e96703. doi: 10.1172/jci.insight.96703. JCI Insight. 2017. PMID: 29263303 Free PMC article.
Fructose metabolism and metabolic disease.
Hannou SA, Haslam DE, McKeown NM, Herman MA. Hannou SA, et al. Among authors: herman ma. J Clin Invest. 2018 Feb 1;128(2):545-555. doi: 10.1172/JCI96702. Epub 2018 Feb 1. J Clin Invest. 2018. PMID: 29388924 Free PMC article. Review.
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
White PJ, McGarrah RW, Grimsrud PA, Tso SC, Yang WH, Haldeman JM, Grenier-Larouche T, An J, Lapworth AL, Astapova I, Hannou SA, George T, Arlotto M, Olson LB, Lai M, Zhang GF, Ilkayeva O, Herman MA, Wynn RM, Chuang DT, Newgard CB. White PJ, et al. Among authors: herman ma. Cell Metab. 2018 Jun 5;27(6):1281-1293.e7. doi: 10.1016/j.cmet.2018.04.015. Epub 2018 May 17. Cell Metab. 2018. PMID: 29779826 Free PMC article.
Sleeve gastrectomy rapidly enhances islet function independently of body weight.
Douros JD, Niu J, Sdao S, Gregg T, Fisher-Wellman K, Bharadwaj M, Molina A, Arumugam R, Martin M, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell J, D'Alessio D. Douros JD, et al. Among authors: herman ma. JCI Insight. 2019 Mar 21;4(6):e126688. doi: 10.1172/jci.insight.126688. eCollection 2019 Mar 21. JCI Insight. 2019. PMID: 30777938 Free PMC article.
182 results