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Page 1
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.
Willemsen L, Prange KHM, Neele AE, van Roomen CPAA, Gijbels M, Griffith GR, Toom MD, Beckers L, Siebeler R, Spann NJ, Chen HJ, Bosmans LA, Gorbatenko A, van Wouw S, Zelcer N, Jacobs H, van Leeuwen F, de Winther MPJ. Willemsen L, et al. Among authors: spann nj. Cell Rep. 2022 Nov 22;41(8):111703. doi: 10.1016/j.celrep.2022.111703. Cell Rep. 2022. PMID: 36417856 Free article.
Transcription factor ISL1 is essential for pacemaker development and function.
Liang X, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans SM. Liang X, et al. Among authors: spann nj. J Clin Invest. 2015 Aug 3;125(8):3256-68. doi: 10.1172/JCI68257. Epub 2015 Jul 20. J Clin Invest. 2015. PMID: 26193633 Free PMC article.
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.
Blanc M, Hsieh WY, Robertson KA, Kropp KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, Craigon M, Ruzsics Z, Haas J, Angulo A, Griffiths WJ, Glass CK, Wang Y, Ghazal P. Blanc M, et al. Among authors: spann nj. Immunity. 2013 Jan 24;38(1):106-18. doi: 10.1016/j.immuni.2012.11.004. Epub 2012 Dec 27. Immunity. 2013. PMID: 23273843 Free PMC article.
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.
Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Spann NJ, et al. Cell. 2012 Sep 28;151(1):138-52. doi: 10.1016/j.cell.2012.06.054. Cell. 2012. PMID: 23021221 Free PMC article.
Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.
Hoeksema MA, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP. Hoeksema MA, et al. Among authors: spann nj. EMBO Mol Med. 2014 Sep;6(9):1124-32. doi: 10.15252/emmm.201404170. EMBO Mol Med. 2014. PMID: 25007801 Free PMC article.
44 results