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Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles.
Wang B, Van Herck S, Chen Y, Bai X, Zhong Z, Deswarte K, Lambrecht BN, Sanders NN, Lienenklaus S, Scheeren HW, David SA, Kiessling F, Lammers T, De Geest BG, Shi Y. Wang B, et al. Among authors: chen y. J Am Chem Soc. 2020 Jul 15;142(28):12133-12139. doi: 10.1021/jacs.0c01928. Epub 2020 Jun 30. J Am Chem Soc. 2020. PMID: 32524819 Free PMC article.
Lipid-Polyglutamate Nanoparticle Vaccine Platform.
Van Lysebetten D, Malfanti A, Deswarte K, Koynov K, Golba B, Ye T, Zhong Z, Kasmi S, Lamoot A, Chen Y, Van Herck S, Lambrecht BN, Sanders NN, Lienenklaus S, David SA, Vicent MJ, De Koker S, De Geest BG. Van Lysebetten D, et al. Among authors: chen y. ACS Appl Mater Interfaces. 2021 Feb 10;13(5):6011-6022. doi: 10.1021/acsami.0c20607. Epub 2021 Jan 28. ACS Appl Mater Interfaces. 2021. PMID: 33507728 Free PMC article.
Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity.
Lamoot A, Jangra S, Laghlali G, Warang P, Singh G, Chang LA, Park SC, Singh G, De Swarte K, Zhong Z, Louage B, De Lombaerde E, Ye T, Chen Y, Cuadrado-Castano S, Lienenklaus S, Sanders NN, Lambrecht BN, García-Sastre A, Schotsaert M, De Geest BG. Lamoot A, et al. Among authors: chen y. Small. 2024 Mar;20(10):e2306892. doi: 10.1002/smll.202306892. Epub 2023 Oct 22. Small. 2024. PMID: 37867244 Free PMC article.
Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in QIV vaccinated mice.
Jangra S, Lamoot A, Singh G, Laghlali G, Chen Y, Yz T, García-Sastre A, De Geest BG, Schotsaert M. Jangra S, et al. Among authors: chen y. bioRxiv [Preprint]. 2024 Jan 15:2024.01.14.575599. doi: 10.1101/2024.01.14.575599. bioRxiv. 2024. Update in: Front Immunol. 2024 Apr 22;15:1370564. doi: 10.3389/fimmu.2024.1370564 PMID: 38293047 Free PMC article. Updated. Preprint.
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