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545 results

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Page 1
Structure-based design of bitopic ligands for the µ-opioid receptor.
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S. Faouzi A, et al. Among authors: roth bl. Nature. 2023 Jan;613(7945):767-774. doi: 10.1038/s41586-022-05588-y. Epub 2022 Nov 30. Nature. 2023. PMID: 36450356 Free PMC article.
Functional selectivity and classical concepts of quantitative pharmacology.
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Urban JD, et al. Among authors: roth bl. J Pharmacol Exp Ther. 2007 Jan;320(1):1-13. doi: 10.1124/jpet.106.104463. Epub 2006 Jun 27. J Pharmacol Exp Ther. 2007. PMID: 16803859 Review.
Structure of the human κ-opioid receptor in complex with JDTic.
Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC. Wu H, et al. Among authors: roth bl. Nature. 2012 Mar 21;485(7398):327-32. doi: 10.1038/nature10939. Nature. 2012. PMID: 22437504 Free PMC article.
Automated design of ligands to polypharmacological profiles.
Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, Simeons FR, Stojanovski L, Prat A, Seidah NG, Constam DB, Bickerton GR, Read KD, Wetsel WC, Gilbert IH, Roth BL, Hopkins AL. Besnard J, et al. Among authors: roth bl. Nature. 2012 Dec 13;492(7428):215-20. doi: 10.1038/nature11691. Nature. 2012. PMID: 23235874 Free PMC article.
Structural features for functional selectivity at serotonin receptors.
Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, Roth BL, Stevens RC. Wacker D, et al. Among authors: roth bl. Science. 2013 May 3;340(6132):615-9. doi: 10.1126/science.1232808. Epub 2013 Mar 21. Science. 2013. PMID: 23519215 Free PMC article.
Structure of the human smoothened receptor bound to an antitumour agent.
Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC. Wang C, et al. Among authors: roth bl. Nature. 2013 May 16;497(7449):338-43. doi: 10.1038/nature12167. Epub 2013 May 1. Nature. 2013. PMID: 23636324 Free PMC article.
Chemotype-selective modes of action of κ-opioid receptor agonists.
Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL. Vardy E, et al. Among authors: roth bl. J Biol Chem. 2013 Nov 29;288(48):34470-83. doi: 10.1074/jbc.M113.515668. Epub 2013 Oct 11. J Biol Chem. 2013. PMID: 24121503 Free PMC article.
Molecular control of δ-opioid receptor signalling.
Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC. Fenalti G, et al. Among authors: roth bl. Nature. 2014 Feb 13;506(7487):191-6. doi: 10.1038/nature12944. Epub 2014 Jan 12. Nature. 2014. PMID: 24413399 Free PMC article.
Allosteric sodium in class A GPCR signaling.
Katritch V, Fenalti G, Abola EE, Roth BL, Cherezov V, Stevens RC. Katritch V, et al. Among authors: roth bl. Trends Biochem Sci. 2014 May;39(5):233-44. doi: 10.1016/j.tibs.2014.03.002. Epub 2014 Apr 21. Trends Biochem Sci. 2014. PMID: 24767681 Free PMC article.
545 results