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Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli.
Sareila O, Hämäläinen M, Nissinen E, Kankaanranta H, Moilanen E. Sareila O, et al. Among authors: hamalainen m. J Pharmacol Exp Ther. 2008 Feb;324(2):858-66. doi: 10.1124/jpet.107.129114. Epub 2007 Nov 26. J Pharmacol Exp Ther. 2008. PMID: 18039960
609 results