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Page 1
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.
Sebastiani J, Puxeddu M, Nalli M, Bai R, Altieri L, Rovella P, Gaudio E, Trisciuoglio D, Spriano F, Lavia P, Fionda C, Masci D, Urbani A, Bigogno C, Dondio G, Hamel E, Bertoni F, Silvestri R, La Regina G. Sebastiani J, et al. Among authors: masci d. Eur J Med Chem. 2023 Jan 15;246:114997. doi: 10.1016/j.ejmech.2022.114997. Epub 2022 Dec 5. Eur J Med Chem. 2023. PMID: 36502578
Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.
Famiglini V, La Regina G, Coluccia A, Masci D, Brancale A, Badia R, Riveira-Muñoz E, Esté JA, Crespan E, Brambilla A, Maga G, Catalano M, Limatola C, Formica FR, Cirilli R, Novellino E, Silvestri R. Famiglini V, et al. Among authors: masci d. J Med Chem. 2017 Aug 10;60(15):6528-6547. doi: 10.1021/acs.jmedchem.6b01906. Epub 2017 Jul 5. J Med Chem. 2017. PMID: 28628334 Free article.
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.
La Regina G, Bai R, Coluccia A, Naccarato V, Famiglini V, Nalli M, Masci D, Verrico A, Rovella P, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Vultaggio S, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R. La Regina G, et al. Among authors: masci d. Eur J Med Chem. 2018 May 25;152:283-297. doi: 10.1016/j.ejmech.2018.04.042. Epub 2018 Apr 25. Eur J Med Chem. 2018. PMID: 29730191
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: Structure-activity relationships and mode of action studies.
Masci D, Hind C, Islam MK, Toscani A, Clifford M, Coluccia A, Conforti I, Touitou M, Memdouh S, Wei X, La Regina G, Silvestri R, Sutton JM, Castagnolo D. Masci D, et al. Eur J Med Chem. 2019 Sep 15;178:500-514. doi: 10.1016/j.ejmech.2019.05.087. Epub 2019 Jun 3. Eur J Med Chem. 2019. PMID: 31202995
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains.
Nalli M, Armijos Rivera JI, Masci D, Coluccia A, Badia R, Riveira-Muñoz E, Brambilla A, Cinquina E, Turriziani O, Falasca F, Catalano M, Limatola C, Esté JA, Maga G, Silvestri R, Crespan E, La Regina G. Nalli M, et al. Among authors: masci d. Eur J Med Chem. 2020 Dec 15;208:112696. doi: 10.1016/j.ejmech.2020.112696. Epub 2020 Aug 11. Eur J Med Chem. 2020. PMID: 32883642
Anticancer Activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a New Dishevelled 1 Inhibitor.
Coluccia A, Bufano M, La Regina G, Puxeddu M, Toto A, Paone A, Bouzidi A, Musto G, Badolati N, Orlando V, Biagioni S, Masci D, Cantatore C, Cirilli R, Cutruzzolà F, Gianni S, Stornaiuolo M, Silvestri R. Coluccia A, et al. Among authors: masci d. Cancers (Basel). 2022 Mar 7;14(5):1358. doi: 10.3390/cancers14051358. Cancers (Basel). 2022. PMID: 35267666 Free PMC article.
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor.
Puxeddu M, Wu J, Bai R, D'Ambrosio M, Nalli M, Coluccia A, Manetto S, Ciogli A, Masci D, Urbani A, Fionda C, Coni S, Bordone R, Canettieri G, Bigogno C, Dondio G, Hamel E, Liu T, Silvestri R, La Regina G. Puxeddu M, et al. Among authors: d ambrosio m, masci d. J Med Chem. 2022 Dec 8;65(23):15805-15818. doi: 10.1021/acs.jmedchem.2c01457. Epub 2022 Nov 17. J Med Chem. 2022. PMID: 36395526 Free PMC article.
Emerging Direct Targeting β-Catenin Agents.
Nalli M, Masci D, Urbani A, La Regina G, Silvestri R. Nalli M, et al. Among authors: masci d. Molecules. 2022 Nov 10;27(22):7735. doi: 10.3390/molecules27227735. Molecules. 2022. PMID: 36431838 Free PMC article. Review.
27 results