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Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance.
Zia S, Hammond BP, Zirngibl M, Sizov A, Baaklini CS, Panda SP, Ho MFS, Lee KV, Mainali A, Burr MK, Williams S, Caprariello AV, Power C, Simmen T, Kerr BJ, Plemel JR. Zia S, et al. Among authors: caprariello av. Mol Neurodegener. 2022 Dec 13;17(1):82. doi: 10.1186/s13024-022-00584-2. Mol Neurodegener. 2022. PMID: 36514132 Free PMC article.
Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion.
Plemel JR, Stratton JA, Michaels NJ, Rawji KS, Zhang E, Sinha S, Baaklini CS, Dong Y, Ho M, Thorburn K, Friedman TN, Jawad S, Silva C, Caprariello AV, Hoghooghi V, Yue J, Jaffer A, Lee K, Kerr BJ, Midha R, Stys PK, Biernaskie J, Yong VW. Plemel JR, et al. Among authors: caprariello av. Sci Adv. 2020 Jan 15;6(3):eaay6324. doi: 10.1126/sciadv.aay6324. eCollection 2020 Jan. Sci Adv. 2020. PMID: 31998844 Free PMC article.
Biochemically altered myelin triggers autoimmune demyelination.
Caprariello AV, Rogers JA, Morgan ML, Hoghooghi V, Plemel JR, Koebel A, Tsutsui S, Dunn JF, Kotra LP, Ousman SS, Wee Yong V, Stys PK. Caprariello AV, et al. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5528-5533. doi: 10.1073/pnas.1721115115. Epub 2018 May 4. Proc Natl Acad Sci U S A. 2018. PMID: 29728463 Free PMC article.
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