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Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs.
Cunningham MJ, Bock HA, Serrano IC, Bechand B, Vidyadhara DJ, Bonniwell EM, Lankri D, Duggan P, Nazarova AL, Cao AB, Calkins MM, Khirsariya P, Hwu C, Katritch V, Chandra SS, McCorvy JD, Sames D. Cunningham MJ, et al. Among authors: bock ha. ACS Chem Neurosci. 2023 Jan 4;14(1):119-135. doi: 10.1021/acschemneuro.2c00597. Epub 2022 Dec 15. ACS Chem Neurosci. 2023. PMID: 36521179 Free PMC article.
Identification of 5-HT2A Receptor Signaling Pathways Responsible for Psychedelic Potential.
Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD. Wallach J, et al. Among authors: bock ha. bioRxiv [Preprint]. 2023 Jul 31:2023.07.29.551106. doi: 10.1101/2023.07.29.551106. bioRxiv. 2023. Update in: Nat Commun. 2023 Dec 15;14(1):8221. doi: 10.1038/s41467-023-44016-1 PMID: 37577474 Free PMC article. Updated. Preprint.
Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential.
Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD. Wallach J, et al. Among authors: bock ha. Nat Commun. 2023 Dec 15;14(1):8221. doi: 10.1038/s41467-023-44016-1. Nat Commun. 2023. PMID: 38102107 Free PMC article.
Bioisosteric analogs of MDMA with improved pharmacological profile.
Alberto-Silva AS, Hemmer S, Bock HA, Alves da Silva L, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH. Alberto-Silva AS, et al. Among authors: bock ha. bioRxiv [Preprint]. 2024 Apr 11:2024.04.08.588083. doi: 10.1101/2024.04.08.588083. bioRxiv. 2024. Update in: J Neurochem. 2024 Sep;168(9):2022-2042. doi: 10.1111/jnc.16149 PMID: 38645142 Free PMC article. Updated. Preprint.
N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels.
Denomme N, Hernandez CC, Bock HA, Ohana RF, Bakshi S, Sherwood AM, McCorvy JD, Daley PF, Callaway WB, Hull JM, Alt A, Isom LL, Cozzi NV. Denomme N, et al. Among authors: bock ha. Mol Pharmacol. 2024 Jul 17;106(2):92-106. doi: 10.1124/molpharm.123.000837. Mol Pharmacol. 2024. PMID: 38821630
Bioisosteric analogs of MDMA: Improving the pharmacological profile?
Alberto-Silva AS, Hemmer S, Bock HA, da Silva LA, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH. Alberto-Silva AS, et al. Among authors: bock ha. J Neurochem. 2024 Sep;168(9):2022-2042. doi: 10.1111/jnc.16149. Epub 2024 Jun 19. J Neurochem. 2024. PMID: 38898705
Potent and Selective Human 5-HT2B Serotonin Receptor Antagonists: 4'-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity.
Tosh DK, Pavan M, Clark AA, Lammers J, Villano S, Marri S, Sgambellone S, Choi S, Lee J, Ivancich MS, Bock HA, Campbell RG, Lewicki SA, Levitan IM, Chen E, Liu N, Demby T, Gavrilova O, Gao ZG, Lucarini L, McCorvy JD, Jacobson KA. Tosh DK, et al. Among authors: bock ha. J Med Chem. 2024 Dec 12;67(23):21264-21291. doi: 10.1021/acs.jmedchem.4c02174. Epub 2024 Nov 26. J Med Chem. 2024. PMID: 39589936
39 results