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334 results

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Page 1
Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease.
Lay AC, Tran VDT, Nair V, Betin V, Hurcombe JA, Barrington AF, Pope RJ, Burdet F, Mehl F, Kryvokhyzha D, Ahmad A, Sinton MC, Lewis P, Wilson MC, Menon R, Otto E, Heesom KJ, Ibberson M, Looker HC, Nelson RG, Ju W, Kretzler M, Satchell SC, Gomez MF, Coward RJM; BEAt-DKD consortium. Lay AC, et al. Among authors: otto e. Nat Commun. 2024 Nov 19;15(1):10018. doi: 10.1038/s41467-024-54089-1. Nat Commun. 2024. PMID: 39562547 Free PMC article.
Association of Urinary Epidermal Growth Factor, Fatty Acid-Binding Protein 3, and Vascular Cell Adhesion Molecule 1 Levels with the Progression of Early Diabetic Kidney Disease.
Keller F, Denicolò S, Leierer J, Kruus M, Heinzel A, Kammer M, Ju W, Nair V, Burdet F, Ibberson M, Menon R, Otto E, Choi YJ, Pyle L, Ladd P, Bjornstad PM, Eder S, Rosivall L, Mark PB, Wiecek A, Heerspink HJL, Kretzler M, Oberbauer R, Mayer G, Perco P. Keller F, et al. Among authors: otto e. Kidney Blood Press Res. 2024;49(1):1013-1025. doi: 10.1159/000542267. Epub 2024 Nov 7. Kidney Blood Press Res. 2024. PMID: 39510044 Free article.
Attenuated kidney oxidative metabolism in young adults with type 1 diabetes.
Choi YJ, Richard G, Zhang G, Hodgin JB, Demeke DS, Yang Y, Schaub JA, Tamayo IM, Gurung BK, Naik AS, Nair V, Birznieks C, MacDonald A, Narongkiatikhun P, Gross S, Driscoll L, Flynn M, Tommerdahl K, Nadeau KJ, Shah VN, Vigers T, Snell-Bergeon JK, Kendrick J, van Raalte DH, Li LP, Prasad P, Ladd P, Chin BB, Cherney DZ, McCown PJ, Alakwaa F, Otto EA, Brosius FC, Saulnier PJ, Puelles VG, Goodrich JA, Street K, Venkatachalam MA, Ruiz A, de Boer IH, Nelson RG, Pyle L, Blondin DP, Sharma K, Kretzler M, Bjornstad P. Choi YJ, et al. Among authors: otto ea. J Clin Invest. 2024 Oct 22;134(24):e183984. doi: 10.1172/JCI183984. J Clin Invest. 2024. PMID: 39436695 Free PMC article. Clinical Trial.
Plasma Proteins Associated with Chronic Histopathologic Lesions on Kidney Biopsy.
Kim T, Surapaneni AL, Schmidt IM, Eadon MT, Kalim S, Srivastava A, Palsson R, Stillman IE, Hodgin JB, Menon R, Otto EA, Coresh J, Grams ME, Waikar SS, Rhee EP; Kidney Precision Medicine Project. Kim T, et al. Among authors: otto ea. J Am Soc Nephrol. 2024 Jul 1;35(7):910-922. doi: 10.1681/ASN.0000000000000358. Epub 2024 Apr 24. J Am Soc Nephrol. 2024. PMID: 38656806
Increased β2-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn D, Knapstein PR, Otto E, Köhli P, Sevecke J, Graef F, Graffmann C, Fuchs M, Jiang S, Rickert M, Erdmann C, Appelt J, Revend L, Küttner Q, Witte J, Rahmani A, Duda G, Xie W, Donat A, Schinke T, Ivanov A, Tchouto MN, Beule D, Frosch KH, Baranowsky A, Tsitsilonis S, Keller J. Jahn D, et al. Among authors: otto e. Sci Transl Med. 2024 Apr 17;16(743):eadk9129. doi: 10.1126/scitranslmed.adk9129. Epub 2024 Apr 17. Sci Transl Med. 2024. PMID: 38630849
Integrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury.
Anandakrishnan N, Yi Z, Sun Z, Liu T, Haydak J, Eddy S, Jayaraman P, DeFronzo S, Saha A, Sun Q, Yang D, Mendoza A, Mosoyan G, Wen HH, Schaub JA, Fu J, Kehrer T, Menon R, Otto EA, Godfrey B, Suarez-Farinas M, Leffters S, Twumasi A, Meliambro K, Charney AW, García-Sastre A, Campbell KN, Gusella GL, He JC, Miorin L, Nadkarni GN, Wisnivesky J, Li H, Kretzler M, Coca SG, Chan L, Zhang W, Azeloglu EU. Anandakrishnan N, et al. Among authors: otto ea. medRxiv [Preprint]. 2024 Mar 19:2024.03.18.24304401. doi: 10.1101/2024.03.18.24304401. medRxiv. 2024. PMID: 38562892 Free PMC article. Preprint.
The chromatin landscape of healthy and injured cell types in the human kidney.
Gisch DL, Brennan M, Lake BB, Basta J, Keller MS, Melo Ferreira R, Akilesh S, Ghag R, Lu C, Cheng YH, Collins KS, Parikh SV, Rovin BH, Robbins L, Stout L, Conklin KY, Diep D, Zhang B, Knoten A, Barwinska D, Asghari M, Sabo AR, Ferkowicz MJ, Sutton TA, Kelly KJ, De Boer IH, Rosas SE, Kiryluk K, Hodgin JB, Alakwaa F, Winfree S, Jefferson N, Türkmen A, Gaut JP, Gehlenborg N, Phillips CL, El-Achkar TM, Dagher PC, Hato T, Zhang K, Himmelfarb J, Kretzler M, Mollah S; Kidney Precision Medicine Project (KPMP); Jain S, Rauchman M, Eadon MT. Gisch DL, et al. Nat Commun. 2024 Jan 10;15(1):433. doi: 10.1038/s41467-023-44467-6. Nat Commun. 2024. PMID: 38199997 Free PMC article.
Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.
Beamish JA, Telang AC, McElliott MC, Al-Suraimi A, Chowdhury M, Ference-Salo JT, Otto EA, Menon R, Soofi A, Weinberg JM, Patel SR, Dressler GR. Beamish JA, et al. Among authors: otto ea. Kidney Int. 2024 Feb;105(2):312-327. doi: 10.1016/j.kint.2023.10.022. Epub 2023 Nov 17. Kidney Int. 2024. PMID: 37977366
334 results