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Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.
He Y, Brouwers B, Liu H, Liu H, Lawler K, Mendes de Oliveira E, Lee DK, Yang Y, Cox AR, Keogh JM, Henning E, Bounds R, Perdikari A, Ayinampudi V, Wang C, Yu M, Tu L, Zhang N, Yin N, Han J, Scarcelli NA, Yan Z, Conde KM, Potts C, Bean JC, Wang M, Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Xu Y, Sadaf Farooqi I. He Y, et al. Among authors: yin n. Nat Med. 2022 Dec;28(12):2537-2546. doi: 10.1038/s41591-022-02106-5. Epub 2022 Dec 19. Nat Med. 2022. PMID: 36536256 Free PMC article.
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss.
Liu H, He Y, Bai J, Zhang C, Zhang F, Yang Y, Luo H, Yu M, Liu H, Tu L, Zhang N, Yin N, Han J, Yan Z, Scarcelli NA, Conde KM, Wang M, Bean JC, Potts CHS, Wang C, Hu F, Liu F, Xu Y. Liu H, et al. Among authors: yin n. Nat Metab. 2023 Jan;5(1):147-164. doi: 10.1038/s42255-022-00701-x. Epub 2023 Jan 2. Nat Metab. 2023. PMID: 36593271
Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia.
Tu L, Bean JC, He Y, Liu H, Yu M, Liu H, Zhang N, Yin N, Han J, Scarcelli NA, Conde KM, Wang M, Li Y, Feng B, Gao P, Cai ZL, Fukuda M, Xue M, Tong Q, Yang Y, Liao L, Xu J, Wang C, He Y, Xu Y. Tu L, et al. Among authors: yin n. J Clin Invest. 2023 Jul 17;133(14):e163391. doi: 10.1172/JCI163391. J Clin Invest. 2023. PMID: 37261917 Free PMC article.
5-HT Neurons Integrate GABA and Dopamine Inputs to Regulate Meal Initiation.
Conde KM, Wong H, Fang S, Li Y, Yu M, Deng Y, Liu Q, Fang X, Wang M, Shi Y, Ginnard OZ, Yang Y, Tu L, Liu H, Liu H, Yin N, Bean JC, Han J, Burt ME, Jossy SV, Yang Y, Tong Q, Arenkiel BR, Wang C, He Y, Xu Y. Conde KM, et al. Among authors: yin n. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591360. doi: 10.1101/2024.04.26.591360. bioRxiv. 2024. Update in: Metabolism. 2024 Dec 10;163:156099. doi: 10.1016/j.metabol.2024.156099 PMID: 38746314 Free PMC article. Updated. Preprint.
A Light-Responsive Neural Circuit Suppresses Feeding.
Liu H, Qu N, Gonzalez NV, Palma MA, Chen H, Xiong J, Choubey A, Li Y, Li X, Yu M, Liu H, Tu L, Zhang N, Yin N, Conde KM, Wang M, Bean JC, Han J, Scarcelli NA, Yang Y, Saito K, Cui H, Tong Q, Sun Z, Wang C, Cai X, Lu L, He Y, Xu Y. Liu H, et al. Among authors: yin n. J Neurosci. 2024 Jul 24;44(30):e2192232024. doi: 10.1523/JNEUROSCI.2192-23.2024. J Neurosci. 2024. PMID: 38897723
Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans.
Liu H, He Y, Liu H, Brouwers B, Yin N, Lawler K, Keogh JM, Henning E, Lee DK, Yu M, Tu L, Zhang N, Conde KM, Han J, Yan Z, Scarcelli NA, Liao L, Xu J, Tong Q, Zheng H, Sun Z, Yang Y, Wang C, He Y, Farooqi IS, Xu Y. Liu H, et al. Among authors: yin n. Sci Adv. 2024 Jun 28;10(26):eadl2675. doi: 10.1126/sciadv.adl2675. Epub 2024 Jun 28. Sci Adv. 2024. PMID: 38941473 Free PMC article.
Loss of transient receptor potential channel 5 causes obesity and postpartum depression.
Li Y, Cacciottolo TM, Yin N, He Y, Liu H, Liu H, Yang Y, Henning E, Keogh JM, Lawler K, Mendes de Oliveira E, Gardner EJ, Kentistou KA, Laouris P, Bounds R, Ong KK, Perry JRB, Barroso I, Tu L, Bean JC, Yu M, Conde KM, Wang M, Ginnard O, Fang X, Tong L, Han J, Darwich T, Williams KW, Yang Y, Wang C, Joss S, Firth HV, Xu Y, Farooqi IS. Li Y, et al. Among authors: yin n. Cell. 2024 Aug 8;187(16):4176-4192.e17. doi: 10.1016/j.cell.2024.06.001. Epub 2024 Jul 2. Cell. 2024. PMID: 38959890 Free article.
Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons.
Yu M, Yin N, Feng B, Gao P, Yu K, Liu H, Liu H, Li Y, Ginnard OZ, Conde KM, Wang M, Fang X, Tu L, Bean JC, Liu Q, Deng Y, Yang Y, Han J, Jossy SV, Burt ML, Wong HZ, Yang Y, Arenkiel BR, He Y, Guo S, Gourdy P, Arnal JF, Lenfant F, Wang Z, Wang C, He Y, Xu Y. Yu M, et al. Among authors: yin n. Sci Adv. 2024 Oct 4;10(40):eadp0696. doi: 10.1126/sciadv.adp0696. Epub 2024 Oct 2. Sci Adv. 2024. PMID: 39356770 Free PMC article.
Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation.
Conde KM, Wong H, Fang S, Li Y, Yu M, Deng Y, Liu Q, Fang X, Wang M, Shi Y, Ginnard OZ, Yang Y, Tu L, Liu H, Liu H, Yin N, Bean JC, Han J, Burt ME, Jossy SV, Yang Y, Tong Q, Arenkiel BR, Wang C, He Y, Xu Y. Conde KM, et al. Among authors: yin n. Metabolism. 2024 Dec 10;163:156099. doi: 10.1016/j.metabol.2024.156099. Online ahead of print. Metabolism. 2024. PMID: 39667432 Free article.
1,039 results