Venkatakrishnan K - Search Results

1

Variable or variate? A conundrum in pharmacometrics exposure-response models.

Grisic AM, Venkatakrishnan K, French J, Khandelwal A. Grisic AM, et al. Among authors: venkatakrishnan k. CPT Pharmacometrics Syst Pharmacol. 2023 Feb;12(2):144-147. doi: 10.1002/psp4.12905. Epub 2022 Dec 29. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 36537836 Free PMC article.

2

Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment.

Venkatakrishnan K, Obach RS, Rostami-Hodjegan A. Venkatakrishnan K, et al. Xenobiotica. 2007 Oct-Nov;37(10-11):1225-56. doi: 10.1080/00498250701670945. Xenobiotica. 2007. PMID: 17968744 Review.

3

Pharmacokinetic and pharmacodynamic study of two doses of bortezomib in patients with relapsed multiple myeloma.

Reece DE, Sullivan D, Lonial S, Mohrbacher AF, Chatta G, Shustik C, Burris H 3rd, Venkatakrishnan K, Neuwirth R, Riordan WJ, Karol M, von Moltke LL, Acharya M, Zannikos P, Keith Stewart A. Reece DE, et al. Among authors: venkatakrishnan k. Cancer Chemother Pharmacol. 2011 Jan;67(1):57-67. doi: 10.1007/s00280-010-1283-3. Epub 2010 Mar 20. Cancer Chemother Pharmacol. 2011. PMID: 20306195 Free PMC article. Clinical Trial.

4

Pharmacokinetics and safety of bortezomib in patients with advanced malignancies and varying degrees of liver dysfunction: phase I NCI Organ Dysfunction Working Group Study NCI-6432.

LoRusso PM, Venkatakrishnan K, Ramanathan RK, Sarantopoulos J, Mulkerin D, Shibata SI, Hamilton A, Dowlati A, Mani S, Rudek MA, Takimoto CH, Neuwirth R, Esseltine DL, Ivy P. LoRusso PM, et al. Among authors: venkatakrishnan k. Clin Cancer Res. 2012 May 15;18(10):2954-63. doi: 10.1158/1078-0432.CCR-11-2873. Epub 2012 Mar 6. Clin Cancer Res. 2012. PMID: 22394984 Free PMC article. Clinical Trial.

5

Kinetics and dynamics of intravenous adinazolam, N-desmethyl adinazolam, and alprazolam in healthy volunteers.

Venkatakrishnan K, Culm KE, Ehrenberg BL, Harmatz JS, Corbett KE, Fleishaker JC, Greenblatt DJ. Venkatakrishnan K, et al. J Clin Pharmacol. 2005 May;45(5):529-37. doi: 10.1177/0091270004269105. J Clin Pharmacol. 2005. PMID: 15831776 Clinical Trial.

6

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions.

Obach RS, Walsky RL, Venkatakrishnan K, Gaman EA, Houston JB, Tremaine LM. Obach RS, et al. Among authors: venkatakrishnan k. J Pharmacol Exp Ther. 2006 Jan;316(1):336-48. doi: 10.1124/jpet.105.093229. Epub 2005 Sep 28. J Pharmacol Exp Ther. 2006. PMID: 16192315

7

Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation.

Venkatakrishnan K, Obach RS. Venkatakrishnan K, et al. Curr Drug Metab. 2007 Jun;8(5):449-62. doi: 10.2174/138920007780866861. Curr Drug Metab. 2007. PMID: 17584016

8

In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach.

Obach RS, Walsky RL, Venkatakrishnan K, Houston JB, Tremaine LM. Obach RS, et al. Among authors: venkatakrishnan k. Clin Pharmacol Ther. 2005 Dec;78(6):582-92. doi: 10.1016/j.clpt.2005.09.004. Clin Pharmacol Ther. 2005. PMID: 16338274 Review. No abstract available.

9

Metabolism and disposition of a gamma-aminobutyric acid type A receptor partial agonist in humans.

Shaffer CL, Gunduz M, Vaz AD, Venkatakrishnan K, Burstein AH. Shaffer CL, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2008 Apr;36(4):655-62. doi: 10.1124/dmd.107.019760. Epub 2008 Jan 7. Drug Metab Dispos. 2008. PMID: 18180269

10

Biotransformation of an alpha4beta2 nicotinic acetylcholine receptor partial agonist in sprague-dawley rats and the dispositional characterization of its N-carbamoyl glucuronide metabolite.

Shaffer CL, Ryder TF, Venkatakrishnan K, Henne IK, O'Connell TN. Shaffer CL, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2009 Jul;37(7):1480-9. doi: 10.1124/dmd.109.027037. Epub 2009 Apr 1. Drug Metab Dispos. 2009. PMID: 19339375

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