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Page 1
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.
Griess K, Rieck M, Müller N, Karsai G, Hartwig S, Pelligra A, Hardt R, Schlegel C, Kuboth J, Uhlemeyer C, Trenkamp S, Jeruschke K, Weiss J, Peifer-Weiss L, Xu W, Cames S, Yi X, Cnop M, Beller M, Stark H, Kondadi AK, Reichert AS, Markgraf D, Wammers M, Häussinger D, Kuss O, Lehr S, Eizirik D, Lickert H, Lammert E, Roden M, Winter D, Al-Hasani H, Höglinger D, Hornemann T, Brüning JC, Belgardt BF. Griess K, et al. Among authors: karsai g. Nat Cell Biol. 2023 Jan;25(1):20-29. doi: 10.1038/s41556-022-01027-2. Epub 2022 Dec 21. Nat Cell Biol. 2023. PMID: 36543979 Free PMC article.
The BET Protein Inhibitor Apabetalone Rescues Diabetes-Induced Impairment of Angiogenic Response by Epigenetic Regulation of Thrombospondin-1.
Mohammed SA, Albiero M, Ambrosini S, Gorica E, Karsai G, Caravaggi CM, Masi S, Camici GG, Wenzl FA, Calderone V, Madeddu P, Sciarretta S, Matter CM, Spinetti G, Lüscher TF, Ruschitzka F, Costantino S, Fadini GP, Paneni F. Mohammed SA, et al. Among authors: karsai g. Antioxid Redox Signal. 2022 Apr;36(10-12):667-684. doi: 10.1089/ars.2021.0127. Epub 2022 Apr 1. Antioxid Redox Signal. 2022. PMID: 34913726
DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans.
Karsai G, Kraft F, Haag N, Korenke GC, Hänisch B, Othman A, Suriyanarayanan S, Steiner R, Knopp C, Mull M, Bergmann M, Schröder JM, Weis J, Elbracht M, Begemann M, Hornemann T, Kurth I. Karsai G, et al. J Clin Invest. 2019 Mar 1;129(3):1229-1239. doi: 10.1172/JCI124159. Epub 2019 Feb 11. J Clin Invest. 2019. PMID: 30620338 Free PMC article.
Inhibition of de novo ceramide synthesis by sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes.
Velagapudi S, Karsai G, Karsai M, Mohammed SA, Montecucco F, Liberale L, Lee H, Carbone F, Adami GF, Yang K, Crucet M, Stein S, Paneni F, Lapikova-Bryhinska T, Jang HD, Kraler S, Vdovenko D, Züllig RA, Camici GG, Kim HS, Laaksonen R, Gerber PA, Hornemann T, Akhmedov A, Lüscher TF. Velagapudi S, et al. Among authors: karsai g. Cardiovasc Res. 2024 Sep 21;120(11):1265-1278. doi: 10.1093/cvr/cvae100. Cardiovasc Res. 2024. PMID: 38739545
Structure-function relationships of HDL in diabetes and coronary heart disease.
Cardner M, Yalcinkaya M, Goetze S, Luca E, Balaz M, Hunjadi M, Hartung J, Shemet A, Kränkel N, Radosavljevic S, Keel M, Othman A, Karsai G, Hornemann T, Claassen M, Liebisch G, Carreira E, Ritsch A, Landmesser U, Krützfeldt J, Wolfrum C, Wollscheid B, Beerenwinkel N, Rohrer L, von Eckardstein A. Cardner M, et al. Among authors: karsai g. JCI Insight. 2020 Jan 16;5(1):e131491. doi: 10.1172/jci.insight.131491. JCI Insight. 2020. PMID: 31830004 Free PMC article.
Discovery and Mechanism of Action of Small Molecule Inhibitors of Ceramidases.
Healey RD, Saied EM, Cong X, Karsai G, Gabellier L, Saint-Paul J, Del Nero E, Jeannot S, Drapeau M, Fontanel S, Maurel D, Basu S, Leyrat C, Golebiowski J, Bossis G, Bechara C, Hornemann T, Arenz C, Granier S. Healey RD, et al. Among authors: karsai g. Angew Chem Int Ed Engl. 2022 Jan 10;61(2):e202109967. doi: 10.1002/anie.202109967. Epub 2021 Nov 25. Angew Chem Int Ed Engl. 2022. PMID: 34668624
18 results