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Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV. Freedman BS, et al. Nat Commun. 2015 Oct 23;6:8715. doi: 10.1038/ncomms9715. Nat Commun. 2015. PMID: 26493500 Free PMC article.
Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development.
Kim YK, Refaeli I, Brooks CR, Jing P, Gulieva RE, Hughes MR, Cruz NM, Liu Y, Churchill AJ, Wang Y, Fu H, Pippin JW, Lin LY, Shankland SJ, Vogl AW, McNagny KM, Freedman BS. Kim YK, et al. Among authors: freedman bs. Stem Cells. 2017 Dec;35(12):2366-2378. doi: 10.1002/stem.2707. Epub 2017 Sep 29. Stem Cells. 2017. PMID: 28905451 Free PMC article.
CRISPR Gene Editing in the Kidney.
Cruz NM, Freedman BS. Cruz NM, et al. Among authors: freedman bs. Am J Kidney Dis. 2018 Jun;71(6):874-883. doi: 10.1053/j.ajkd.2018.02.347. Epub 2018 Mar 30. Am J Kidney Dis. 2018. PMID: 29606501 Free PMC article. Review.
High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.
Czerniecki SM, Cruz NM, Harder JL, Menon R, Annis J, Otto EA, Gulieva RE, Islas LV, Kim YK, Tran LM, Martins TJ, Pippin JW, Fu H, Kretzler M, Shankland SJ, Himmelfarb J, Moon RT, Paragas N, Freedman BS. Czerniecki SM, et al. Among authors: freedman bs. Cell Stem Cell. 2018 Jun 1;22(6):929-940.e4. doi: 10.1016/j.stem.2018.04.022. Epub 2018 May 17. Cell Stem Cell. 2018. PMID: 29779890 Free PMC article.
Organoid single cell profiling identifies a transcriptional signature of glomerular disease.
Harder JL, Menon R, Otto EA, Zhou J, Eddy S, Wys NL, O'Connor C, Luo J, Nair V, Cebrian C, Spence JR, Bitzer M, Troyanskaya OG, Hodgin JB, Wiggins RC, Freedman BS, Kretzler M; European Renal cDNA Bank (ERCB); Nephrotic Syndrome Study Network (NEPTUNE). Harder JL, et al. Among authors: freedman bs. JCI Insight. 2019 Jan 10;4(1):e122697. doi: 10.1172/jci.insight.122697. JCI Insight. 2019. PMID: 30626756 Free PMC article.
Graft immaturity and safety concerns in transplanted human kidney organoids.
Nam SA, Seo E, Kim JW, Kim HW, Kim HL, Kim K, Kim TM, Ju JH, Gomez IG, Uchimura K, Humphreys BD, Yang CW, Lee JY, Kim J, Cho DW, Freedman BS, Kim YK. Nam SA, et al. Among authors: freedman bs. Exp Mol Med. 2019 Nov 28;51(11):1-13. doi: 10.1038/s12276-019-0336-x. Exp Mol Med. 2019. PMID: 31776328 Free PMC article.
61 results