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A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease.
Lin C, DiCioccio RA, Haykal T, McManigle WC, Li Z, Anand SM, Poe JC, Bracken SJ, Jia W, Alyea EP 3rd, Cardones AR, Choi T, Gasparetto C, Grunwald MR, Hennig T, Kang Y, Long GD, Lopez R, Martin M, Minor KK, Quinones VLP, Sung AD, Wiggins K, Chao NJ, Horwitz ME, Rizzieri DA, Sarantopoulos S. Lin C, et al. Among authors: poe jc. Transplant Cell Ther. 2023 Mar;29(3):179.e1-179.e10. doi: 10.1016/j.jtct.2022.12.015. Epub 2022 Dec 25. Transplant Cell Ther. 2023. PMID: 36577483 Free PMC article. Clinical Trial.
Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.
Flynn R, Allen JL, Luznik L, MacDonald KP, Paz K, Alexander KA, Vulic A, Du J, Panoskaltsis-Mortari A, Taylor PA, Poe JC, Serody JS, Murphy WJ, Hill GR, Maillard I, Koreth J, Cutler CS, Soiffer RJ, Antin JH, Ritz J, Chao NJ, Clynes RA, Sarantopoulos S, Blazar BR. Flynn R, et al. Among authors: poe jc. Blood. 2015 Jun 25;125(26):4085-94. doi: 10.1182/blood-2014-08-595470. Epub 2015 Apr 7. Blood. 2015. PMID: 25852057 Free PMC article.
An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.
Poe JC, Jia W, Su H, Anand S, Rose JJ, Tata PV, Suthers AN, Jones CD, Kuan PF, Vincent BG, Serody JS, Horwitz ME, Ho VT, Pavletic SZ, Hakim FT, Owzar K, Zhang D, Blazar BR, Siebel CW, Chao NJ, Maillard I, Sarantopoulos S. Poe JC, et al. Blood. 2017 Nov 9;130(19):2131-2145. doi: 10.1182/blood-2017-05-782466. Epub 2017 Aug 29. Blood. 2017. PMID: 28851699 Free PMC article. Clinical Trial.
SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.
Poe JC, Jia W, Di Paolo JA, Reyes NJ, Kim JY, Su H, Sundy JS, Cardones AR, Perez VL, Chen BJ, Chao NJ, Cardona DM, Saban DR, Sarantopoulos S. Poe JC, et al. JCI Insight. 2018 Oct 4;3(19):e122430. doi: 10.1172/jci.insight.122430. JCI Insight. 2018. PMID: 30282825 Free PMC article.
BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.
Jia W, Poe JC, Su H, Anand S, Matsushima GK, Rathmell JC, Maillard I, Radojcic V, Imai K, Reyes NJ, Cardona DM, Li Z, Suthers AN, Curry-Chisolm IM, DiCioccio RA, Saban DR, Chen BJ, Chao NJ, Sarantopoulos S. Jia W, et al. Among authors: poe jc. Blood. 2021 May 6;137(18):2544-2557. doi: 10.1182/blood.2020008040. Blood. 2021. PMID: 33534893 Free PMC article.
Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD.
Poe JC, Fang J, Zhang D, Lee MR, DiCioccio RA, Su H, Qin X, Zhang JY, Visentin J, Bracken SJ, Ho VT, Wang KS, Rose JJ, Pavletic SZ, Hakim FT, Jia W, Suthers AN, Curry-Chisolm IM, Horwitz ME, Rizzieri DA, McManigle WC, Chao NJ, Cardones AR, Xie J, Owzar K, Sarantopoulos S. Poe JC, et al. JCI Insight. 2023 Jun 8;8(11):e169732. doi: 10.1172/jci.insight.169732. JCI Insight. 2023. PMID: 37129971 Free PMC article.
59 results