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Page 1
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Schepers M, Paes D, Tiane A, Rombaut B, Piccart E, van Veggel L, Gervois P, Wolfs E, Lambrichts I, Brullo C, Bruno O, Fedele E, Ricciarelli R, Ffrench-Constant C, Bechler ME, van Schaik P, Baron W, Lefevere E, Wasner K, Grünewald A, Verfaillie C, Baeten P, Broux B, Wieringa P, Hellings N, Prickaerts J, Vanmierlo T. Schepers M, et al. Among authors: vanmierlo t. Brain Behav Immun. 2023 Mar;109:1-22. doi: 10.1016/j.bbi.2022.12.020. Epub 2022 Dec 28. Brain Behav Immun. 2023. PMID: 36584795 Free article.
Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.
Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, LütJohann D, Johnson JD, Brunham LR, Verchere CB, Hayden MR. Kruit JK, et al. Among authors: vanmierlo t. Diabetes. 2012 Mar;61(3):659-64. doi: 10.2337/db11-1341. Epub 2012 Feb 7. Diabetes. 2012. PMID: 22315310 Free PMC article.
Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels.
Weingärtner O, Bogeski I, Kummerow C, Schirmer SH, Husche C, Vanmierlo T, Wagenpfeil G, Hoth M, Böhm M, Lütjohann D, Laufs U. Weingärtner O, et al. Among authors: vanmierlo t. J Steroid Biochem Mol Biol. 2017 May;169:219-225. doi: 10.1016/j.jsbmb.2016.07.016. Epub 2016 Jul 27. J Steroid Biochem Mol Biol. 2017. PMID: 27473562 Clinical Trial.
Dietary plant sterols accumulate in the brain.
Jansen PJ, Lütjohann D, Abildayeva K, Vanmierlo T, Plösch T, Plat J, von Bergmann K, Groen AK, Ramaekers FC, Kuipers F, Mulder M. Jansen PJ, et al. Among authors: vanmierlo t. Biochim Biophys Acta. 2006 Apr;1761(4):445-53. doi: 10.1016/j.bbalip.2006.03.015. Epub 2006 Apr 19. Biochim Biophys Acta. 2006. PMID: 16677856
Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study.
Burg VK, Grimm HS, Rothhaar TL, Grösgen S, Hundsdörfer B, Haupenthal VJ, Zimmer VC, Mett J, Weingärtner O, Laufs U, Broersen LM, Tanila H, Vanmierlo T, Lütjohann D, Hartmann T, Grimm MO. Burg VK, et al. Among authors: vanmierlo t. J Neurosci. 2013 Oct 9;33(41):16072-87. doi: 10.1523/JNEUROSCI.1506-13.2013. J Neurosci. 2013. PMID: 24107941 Free PMC article.
112 results