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Page 1
An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics.
Borhani SG, Levine MZ, Krumpe LH, Wilson J, Henrich CJ, Oâ Keefe BR, Lo D, Sittampalam GS, Godfrey AG, Lunsford RD, Mangalampalli V, Tao D, LeClair CA, Thole A, Frey D, Swartz J, Rao G. Borhani SG, et al. Among authors: leclair ca. bioRxiv [Preprint]. 2022 Dec 20:2022.12.19.521044. doi: 10.1101/2022.12.19.521044. bioRxiv. 2022. Update in: N Biotechnol. 2023 Sep 25;76:13-22. doi: 10.1016/j.nbt.2023.04.003 PMID: 36597541 Free PMC article. Updated. Preprint.
Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors.
Skoumbourdis AP, Leclair CA, Stefan E, Turjanski AG, Maguire W, Titus SA, Huang R, Auld DS, Inglese J, Austin CP, Michnick SW, Xia M, Thomas CJ. Skoumbourdis AP, et al. Among authors: leclair ca. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92. doi: 10.1016/j.bmcl.2009.01.057. Epub 2009 Jan 23. Bioorg Med Chem Lett. 2009. PMID: 19464886 Free PMC article.
Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents.
Yuan P, Tragon T, Xia M, Leclair CA, Skoumbourdis AP, Zheng W, Thomas CJ, Huang R, Austin CP, Chen G, Guitart X. Yuan P, et al. Among authors: leclair ca. Pharmacol Biochem Behav. 2011 May;98(3):349-55. doi: 10.1016/j.pbb.2011.02.001. Epub 2011 Feb 4. Pharmacol Biochem Behav. 2011. PMID: 21296104 Free PMC article.
Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-13C]-Pyruvate.
Ettedgui J, Blackman B, Raju N, Kotler SA, Chekmenev EY, Goodson BM, Merkle H, Woodroofe CC, LeClair CA, Krishna MC, Swenson RE. Ettedgui J, et al. Among authors: leclair ca. J Am Chem Soc. 2024 Jan 10;146(1):946-953. doi: 10.1021/jacs.3c11499. Epub 2023 Dec 28. J Am Chem Soc. 2024. PMID: 38154120 Free PMC article.
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang JK, Michael S, Mierzwa T, Huang W, Walsh MJ, Mott BT, Patel P, Leister W, Maloney DJ, Leclair CA, Rai G, Jadhav A, Peyser BD, Austin CP, Martin SE, Simeonov A, Ferrer M, Staudt LM, Thomas CJ. Mathews Griner LA, et al. Among authors: leclair ca. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2349-54. doi: 10.1073/pnas.1311846111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469833 Free PMC article.
Separation of Betti Reaction Product Enantiomers: Absolute Configuration and Inhibition of Botulinum Neurotoxin A.
Cardellina JH 2nd, Vieira RC, Eccard V, Skerry J, Montgomery V, Campbell Y, Roxas-Duncan V, Leister W, Leclair CA, Maloney DJ, Padula D, Pescitelli G, Khavrutskii I, Hu X, Wallqvist A, Smith LA. Cardellina JH 2nd, et al. Among authors: leclair ca. ACS Med Chem Lett. 2011 Mar 10;2(5):396-401. doi: 10.1021/ml200028z. ACS Med Chem Lett. 2011. PMID: 22102940 Free PMC article.
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors.
Crawford MC, Tripu DR, Barritt SA, Jing Y, Gallimore D, Kales SC, Bhanu NV, Xiong Y, Fang Y, Butler KAT, LeClair CA, Coussens NP, Simeonov A, Garcia BA, Dibble CC, Meier JL. Crawford MC, et al. Among authors: leclair ca. ACS Chem Biol. 2023 Oct 20;18(10):2249-2258. doi: 10.1021/acschembio.3c00293. Epub 2023 Sep 22. ACS Chem Biol. 2023. PMID: 37737090 Free PMC article.
30 results