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De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation.
Xie C, Zhou H, Athanasopoulos V, Shen Q, Zhang Y, Meng X, Burgio G, Arsov T, Lungu AC, Zhang P, Qin Y, Ma J, Wu X, Jiang X, Ding H, Meng Y, Shen N, He Y, Vinuesa CG. Xie C, et al. Among authors: he y. Arthritis Rheumatol. 2023 Jun;75(6):1058-1071. doi: 10.1002/art.42416. Epub 2023 Mar 30. Arthritis Rheumatol. 2023. PMID: 36622335
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
He Y, Gallman AE, Xie C, Shen Q, Ma J, Wolfreys FD, Sandy M, Arsov T, Wu X, Qin Y, Zhang P, Jiang S, Stanley M, Wu P, Tan J, Ding H, Xue H, Chen W, Xu J, Criswell LA, Nititham J, Adamski M, Kitching AR, Cook MC, Cao L, Shen N, Cyster JG, Vinuesa CG. He Y, et al. J Exp Med. 2022 Jan 3;219(1):e20211004. doi: 10.1084/jem.20211004. Epub 2021 Dec 10. J Exp Med. 2022. PMID: 34889940 Free PMC article.
Monocytes asphyxiate germinal centers.
He Y, Vinuesa CG. He Y, et al. Immunity. 2022 Mar 8;55(3):385-387. doi: 10.1016/j.immuni.2022.02.007. Immunity. 2022. PMID: 35263564 Free article.
TLR7 gain-of-function genetic variation causes human lupus.
Brown GJ, Cañete PF, Wang H, Medhavy A, Bones J, Roco JA, He Y, Qin Y, Cappello J, Ellyard JI, Bassett K, Shen Q, Burgio G, Zhang Y, Turnbull C, Meng X, Wu P, Cho E, Miosge LA, Andrews TD, Field MA, Tvorogov D, Lopez AF, Babon JJ, López CA, Gónzalez-Murillo Á, Garulo DC, Pascual V, Levy T, Mallack EJ, Calame DG, Lotze T, Lupski JR, Ding H, Ullah TR, Walters GD, Koina ME, Cook MC, Shen N, de Lucas Collantes C, Corry B, Gantier MP, Athanasopoulos V, Vinuesa CG. Brown GJ, et al. Among authors: he y. Nature. 2022 May;605(7909):349-356. doi: 10.1038/s41586-022-04642-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35477763 Free PMC article.
The transcription factor ZEB2 drives the formation of age-associated B cells.
Dai D, Gu S, Han X, Ding H, Jiang Y, Zhang X, Yao C, Hong S, Zhang J, Shen Y, Hou G, Qu B, Zhou H, Qin Y, He Y, Ma J, Yin Z, Ye Z, Qian J, Jiang Q, Wu L, Guo Q, Chen S, Huang C, Kottyan LC, Weirauch MT, Vinuesa CG, Shen N. Dai D, et al. Among authors: he y. Science. 2024 Jan 26;383(6681):413-421. doi: 10.1126/science.adf8531. Epub 2024 Jan 25. Science. 2024. PMID: 38271512 Free PMC article.
A TNIP1-driven systemic autoimmune disorder with elevated IgG4.
Medhavy A, Athanasopoulos V, Bassett K, He Y, Stanley M, Enosi Tuipulotu D, Cappello J, Brown GJ, Gonzalez-Figueroa P, Turnbull C, Shanmuganandam S, Tummala P, Hart G, Lea-Henry T, Wang H, Nambadan S, Shen Q, Roco JA, Burgio G, Wu P, Cho E, Andrews TD, Field MA, Wu X, Ding H, Guo Q, Shen N, Man SM, Jiang SH, Cook MC, Vinuesa CG. Medhavy A, et al. Among authors: he y. Nat Immunol. 2024 Sep;25(9):1678-1691. doi: 10.1038/s41590-024-01902-0. Epub 2024 Jul 26. Nat Immunol. 2024. PMID: 39060650 Free PMC article.
A global metric of immune health.
Vinuesa CG, He Y, Cook MC. Vinuesa CG, et al. Among authors: he y. Nat Med. 2024 Sep;30(9):2411-2412. doi: 10.1038/s41591-024-03210-4. Nat Med. 2024. PMID: 39237630 No abstract available.
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