Kampourakis T - Search Results

1

Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium.

Tanner BCW, Awinda PO, Agonias KB, Attili S, Blair CA, Thompson MS, Walker LA, Kampourakis T, Campbell KS. Tanner BCW, et al. Among authors: kampourakis t. J Gen Physiol. 2023 Mar 6;155(3):e202213200. doi: 10.1085/jgp.202213200. Epub 2023 Jan 12. J Gen Physiol. 2023. PMID: 36633584 Free PMC article.

2

Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments.

Kampourakis T, Sun YB, Irving M. Kampourakis T, et al. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3039-47. doi: 10.1073/pnas.1602776113. Epub 2016 May 9. Proc Natl Acad Sci U S A. 2016. PMID: 27162358 Free PMC article.

3

Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle.

Zhang X, Kampourakis T, Yan Z, Sevrieva I, Irving M, Sun YB. Zhang X, et al. Among authors: kampourakis t. Elife. 2017 Feb 23;6:e24081. doi: 10.7554/eLife.24081. Elife. 2017. PMID: 28229860 Free PMC article.

4

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament.

Kampourakis T, Zhang X, Sun YB, Irving M. Kampourakis T, et al. J Physiol. 2018 Jan 1;596(1):31-46. doi: 10.1113/JP275050. Epub 2017 Nov 21. J Physiol. 2018. PMID: 29052230 Free PMC article.

5

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I.

Sevrieva IR, Brandmeier B, Ponnam S, Gautel M, Irving M, Campbell KS, Sun YB, Kampourakis T. Sevrieva IR, et al. Among authors: kampourakis t. J Biol Chem. 2020 Apr 3;295(14):4398-4410. doi: 10.1074/jbc.RA119.011945. Epub 2020 Feb 21. J Biol Chem. 2020. PMID: 32086378 Free PMC article.

6

Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7.

Cai F, Kampourakis T, Cockburn KT, Sykes BD. Cai F, et al. Among authors: kampourakis t. ACS Chem Biol. 2022 Jun 17;17(6):1495-1504. doi: 10.1021/acschembio.2c00126. Epub 2022 Jun 1. ACS Chem Biol. 2022. PMID: 35649123

7

Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A.

Sevrieva IR, Ponnam S, Yan Z, Irving M, Kampourakis T, Sun YB. Sevrieva IR, et al. Among authors: kampourakis t. J Biol Chem. 2023 Jan;299(1):102767. doi: 10.1016/j.jbc.2022.102767. Epub 2022 Dec 5. J Biol Chem. 2023. PMID: 36470422 Free PMC article.

8

Discovery of novel cardiac troponin activators using fluorescence polarization-based high throughput screening assays.

Parijat P, Ponnam S, Attili S, Campbell KS, El-Mezgueldi M, Pfuhl M, Kampourakis T. Parijat P, et al. Among authors: kampourakis t. Sci Rep. 2023 Mar 30;13(1):5216. doi: 10.1038/s41598-023-32476-w. Sci Rep. 2023. PMID: 36997544 Free PMC article.

9

Basic science methods for the characterization of variants of uncertain significance in hypertrophic cardiomyopathy.

Doh CY, Kampourakis T, Campbell KS, Stelzer JE. Doh CY, et al. Among authors: kampourakis t. Front Cardiovasc Med. 2023 Aug 1;10:1238515. doi: 10.3389/fcvm.2023.1238515. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37600050 Free PMC article. Review.

10

Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening.

Parijat P, Attili S, Hoare Z, Shattock M, Kenyon V, Kampourakis T. Parijat P, et al. Among authors: kampourakis t. Nat Commun. 2023 Nov 24;14(1):7692. doi: 10.1038/s41467-023-43538-y. Nat Commun. 2023. PMID: 38001148 Free PMC article.

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