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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation.
Marquardt V, Theruvath J, Pauck D, Picard D, Qin N, Blümel L, Maue M, Bartl J, Ahmadov U, Langini M, Meyer FD, Cole A, Cruz-Cruz J, Graef CM, Wölfl M, Milde T, Witt O, Erdreich-Epstein A, Leprivier G, Kahlert U, Stefanski A, Stühler K, Keir ST, Bigner DD, Hauer J, Beez T, Knobbe-Thomsen CB, Fischer U, Felsberg J, Hansen FK, Vibhakar R, Venkatraman S, Cheshier SH, Reifenberger G, Borkhardt A, Kurz T, Remke M, Mitra S. Marquardt V, et al. Among authors: knobbe thomsen cb. J Immunother Cancer. 2023 Jan;11(1):e005871. doi: 10.1136/jitc-2022-005871. J Immunother Cancer. 2023. PMID: 36639156 Free PMC article.
Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.
Brenner D, Brüstle A, Lin GH, Lang PA, Duncan GS, Knobbe-Thomsen CB, St Paul M, Reardon C, Tusche MW, Snow B, Hamilton SR, Pfefferle A, Gilani SO, Ohashi PS, Lang KS, Mak TW. Brenner D, et al. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1060-5. doi: 10.1073/pnas.1323166111. Epub 2014 Jan 7. Proc Natl Acad Sci U S A. 2014. PMID: 24398517 Free PMC article.
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.
Kurniawan H, Franchina DG, Guerra L, Bonetti L, -Baguet LS, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, Binsfeld C, Duncan GS, Farinelle S, Nonnenmacher Y, Haight J, Das Gupta D, Ewen A, Taskesen R, Halder R, Chen Y, Jäger C, Ollert M, Wilmes P, Vasiliou V, Harris IS, Knobbe-Thomsen CB, Turner JD, Mak TW, Lohoff M, Meiser J, Hiller K, Brenner D. Kurniawan H, et al. Among authors: knobbe thomsen cb. Cell Metab. 2020 May 5;31(5):920-936.e7. doi: 10.1016/j.cmet.2020.03.004. Epub 2020 Mar 25. Cell Metab. 2020. PMID: 32213345 Free PMC article.
EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.
An Z, Knobbe-Thomsen CB, Wan X, Fan QW, Reifenberger G, Weiss WA. An Z, et al. Among authors: knobbe thomsen cb. Cancer Res. 2018 Dec 15;78(24):6785-6794. doi: 10.1158/0008-5472.CAN-17-3551. Epub 2018 Nov 6. Cancer Res. 2018. PMID: 30401716 Free PMC article.
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