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Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties.
Nielsen JC, Hjo Rringgaard C, Nygaard MMR, Wester A, Elster L, Porsgaard T, Mikkelsen RB, Rasmussen S, Madsen AN, Schlein M, Vrang N, Rigbolt K, Dalbo Ge LS. Nielsen JC, et al. Among authors: elster l. J Med Chem. 2024 Jul 25;67(14):11814-11826. doi: 10.1021/acs.jmedchem.4c00417. Epub 2024 Jul 8. J Med Chem. 2024. PMID: 38977267 Free PMC article.
Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.
Fernandez-Cachon ML, Pedersen SL, Rigbolt KT, Zhang C, Fabricius K, Hansen HH, Elster L, Fink LN, Schäfer M, Rhee NA, Langholz E, Wandall E, Friis SU, Vilmann P, Kristiansen VB, Schmidt C, Schreiter K, Breitschopf K, Hübschle T, Jorsal T, Vilsbøll T, Schmidt T, Theis S, Knop FK, Larsen PJ, Jelsing J. Fernandez-Cachon ML, et al. Among authors: elster l. Peptides. 2018 Mar;101:32-43. doi: 10.1016/j.peptides.2017.12.024. Epub 2017 Dec 28. Peptides. 2018. PMID: 29289697 Clinical Trial.
Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists.
Sasmal PK, Krishna CV, Adabala SS, Roshaiah M, Rawoof KA, Thadi E, Sukumar KP, Cheera S, Abbineni C, Rao KV, Prasanthi A, Nijhawan K, Jaleel M, Iyer LR, Chaitanya TK, Tiwari NK, Krishna NL, Potluri V, Khanna I, Frimurer TM, Lückmann M, Rist Ø, Elster L, Högberg T. Sasmal PK, et al. Among authors: elster l. Bioorg Med Chem Lett. 2015 Feb 15;25(4):887-92. doi: 10.1016/j.bmcl.2014.12.064. Epub 2015 Jan 6. Bioorg Med Chem Lett. 2015. PMID: 25599839
29 results