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Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis.
Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. Neuwirt E, et al. Among authors: gross cj. Sci Signal. 2023 Jan 17;16(768):eabh1083. doi: 10.1126/scisignal.abh1083. Epub 2023 Jan 17. Sci Signal. 2023. PMID: 36649377
XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.
Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ. Yabal M, et al. Among authors: gross cj, gross o. Cell Rep. 2014 Jun 26;7(6):1796-808. doi: 10.1016/j.celrep.2014.05.008. Epub 2014 May 29. Cell Rep. 2014. PMID: 24882010 Free article.
The Nlrp3 inflammasome admits defeat.
Groß CJ, Groß O. Groß CJ, et al. Among authors: gross o. Trends Immunol. 2015 Jun;36(6):323-4. doi: 10.1016/j.it.2015.05.001. Epub 2015 May 16. Trends Immunol. 2015. PMID: 25991463
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.
Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O. Groß CJ, et al. Among authors: gross o. Immunity. 2016 Oct 18;45(4):761-773. doi: 10.1016/j.immuni.2016.08.010. Epub 2016 Sep 27. Immunity. 2016. PMID: 27692612 Free article.
PKA Has the Gall to Oppose NLRP3.
Groß CJ, Groß O. Groß CJ, et al. Among authors: gross o. Immunity. 2016 Oct 18;45(4):707-709. doi: 10.1016/j.immuni.2016.09.019. Immunity. 2016. PMID: 27760332 Free article. Review.
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity.
Schneider KS, Groß CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Ćiković T, Sodenkamp J, Médard G, Naumann R, Ruland J, Kuster B, Broz P, Groß O. Schneider KS, et al. Among authors: gross cj, gross o. Cell Rep. 2017 Dec 26;21(13):3846-3859. doi: 10.1016/j.celrep.2017.12.018. Cell Rep. 2017. PMID: 29281832 Free PMC article.
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