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Page 1
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis.
Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. Neuwirt E, et al. Among authors: jost pj. Sci Signal. 2023 Jan 17;16(768):eabh1083. doi: 10.1126/scisignal.abh1083. Epub 2023 Jan 17. Sci Signal. 2023. PMID: 36649377
Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST).
Rassner M, Waldeck S, Follo M, Jilg S, Philipp U, Jolic M, Wehrle J, Jost PJ, Peschel C, Illert AL, Duyster J, Scherer F, von Bubnoff N. Rassner M, et al. Among authors: jost pj. Int J Mol Sci. 2023 Mar 12;24(6):5411. doi: 10.3390/ijms24065411. Int J Mol Sci. 2023. PMID: 36982486 Free PMC article.
Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification.
Tretter C, de Andrade Krätzig N, Pecoraro M, Lange S, Seifert P, von Frankenberg C, Untch J, Zuleger G, Wilhelm M, Zolg DP, Dreyer FS, Bräunlein E, Engleitner T, Uhrig S, Boxberg M, Steiger K, Slotta-Huspenina J, Ochsenreither S, von Bubnoff N, Bauer S, Boerries M, Jost PJ, Schenck K, Dresing I, Bassermann F, Friess H, Reim D, Grützmann K, Pfütze K, Klink B, Schröck E, Haller B, Kuster B, Mann M, Weichert W, Fröhling S, Rad R, Hiltensperger M, Krackhardt AM. Tretter C, et al. Among authors: jost pj. Nat Commun. 2023 Aug 2;14(1):4632. doi: 10.1038/s41467-023-39570-7. Nat Commun. 2023. PMID: 37532709 Free PMC article.
Author Correction: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification.
Tretter C, de Andrade Krätzig N, Pecoraro M, Lange S, Seifert P, von Frankenberg C, Untch J, Zuleger G, Wilhelm M, Zolg DP, Dreyer FS, Bräunlein E, Engleitner T, Uhrig S, Boxberg M, Steiger K, Slotta-Huspenina J, Ochsenreither S, von Bubnoff N, Bauer S, Boerries M, Jost PJ, Schenck K, Dresing I, Bassermann F, Friess H, Reim D, Grützmann K, Pfütze K, Klink B, Schröck E, Haller B, Kuster B, Mann M, Weichert W, Fröhling S, Rad R, Hiltensperger M, Krackhardt AM. Tretter C, et al. Among authors: jost pj. Nat Commun. 2024 Mar 15;15(1):2364. doi: 10.1038/s41467-024-46724-8. Nat Commun. 2024. PMID: 38491045 Free PMC article. No abstract available.
Elevated RIPK3 correlates with disease burden in myelofibrosis.
Dill V, Wagner CV, Keller EC, Fernandez-Hernandez FJ, Shoumariyeh K, Odinius TO, Buschhorn L, Hauch RT, Suren C, Hecker JS, Herhaus P, Sandherr M, Schmidt B, Slotta-Huspenina J, Bassermann F, Höckendorf U, Jilg S, Branca C, Vosberg S, Jost PJ. Dill V, et al. Among authors: jost pj. Blood Adv. 2023 Apr 11;7(7):1219-1224. doi: 10.1182/bloodadvances.2021006838. Blood Adv. 2023. PMID: 36453650 Free PMC article. No abstract available.
Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia.
Dill V, Kirmes K, Han J, Klug M, Rosenbaum M, Viggiani G, von Scheidt M, List M, Herhaus P, Ruland J, Bassermann F, Laugwitz KL, Götze KS, Jost PJ, Jilg S, Bloxham CJ, Raake PWJ, Bernlochner I, Bongiovanni D. Dill V, et al. Among authors: jost pj. Platelets. 2024 Dec;35(1):2358244. doi: 10.1080/09537104.2024.2358244. Epub 2024 Jun 7. Platelets. 2024. PMID: 38845541 Free article.
Improved overall survival of metastatic renal cell carcinoma patients in the era of modern tyrosine kinase inhibitors and immune checkpoint inhibitors: results from a real-life, population-based Austrian study comprising three decades of follow-up.
Fluhrer H, Hutterer GC, Golbeck S, Stidl M, Niedrist T, Pichler R, Mischinger J, Seles M, Mannweiler S, Spiegelberg J, Bauernhofer T, Jost PJ, Ahyai S, Zigeuner R, Pichler M, Barth DA. Fluhrer H, et al. Among authors: jost pj. Ther Adv Med Oncol. 2022 Nov 19;14:17588359221134065. doi: 10.1177/17588359221134065. eCollection 2022. Ther Adv Med Oncol. 2022. PMID: 36425872 Free PMC article.
The coming decade in precision oncology: six riddles.
Wahida A, Buschhorn L, Fröhling S, Jost PJ, Schneeweiss A, Lichter P, Kurzrock R. Wahida A, et al. Among authors: jost pj. Nat Rev Cancer. 2023 Jan;23(1):43-54. doi: 10.1038/s41568-022-00529-3. Epub 2022 Nov 24. Nat Rev Cancer. 2023. PMID: 36434139 Review.
Transcriptomic profiling does not refine mastocytosis diagnosis.
Buschhorn L, Odoni DI, Geuder J, Odinius TO, Wagner CV, Jilg S, Höckendorf U, Wahida A, Schlesner M, Reiter A, Jawhar M, Jost PJ. Buschhorn L, et al. Among authors: jost pj. Haematologica. 2023 Nov 1;108(11):3125-3130. doi: 10.3324/haematol.2022.282617. Haematologica. 2023. PMID: 37165843 Free PMC article. No abstract available.
Efficacy and safety of ruxolitinib in patients with newly-diagnosed polycythemia vera: futility analysis of the RuxoBEAT clinical trial of the GSG-MPN study group.
Koschmieder S, Isfort S, Wolf D, Heidel FH, Hochhaus A, Schafhausen P, Griesshammer M, Wolleschak D, Platzbecker U, Döhner K, Jost PJ, Parmentier S, Schaich M, von Bubnoff N, Stegelmann F, Maurer A, Crysandt M, Gezer D, Kortmann M, Franklin J, Frank J, Hellmich M, Brümmendorf TH; German Study Group for Myeloproliferative Neoplasms (GSG-MPN). Koschmieder S, et al. Among authors: jost pj. Ann Hematol. 2023 Feb;102(2):349-358. doi: 10.1007/s00277-022-05080-7. Epub 2022 Dec 23. Ann Hematol. 2023. PMID: 36564535 Free PMC article. Clinical Trial.
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