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An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors.
Singh R, Rossini V, Stockdale SR, Saiz-Gonzalo G, Hanrahan N, D' Souza T, Clooney A, Draper LA, Hill C, Nally K, Shanahan F, Andersson-Engels S, Melgar S. Singh R, et al. Among authors: saiz gonzalo g. Gut Microbes. 2023 Jan-Dec;15(1):2163838. doi: 10.1080/19490976.2022.2163838. Gut Microbes. 2023. PMID: 36656595 Free PMC article.
Regulation of CEACAM Family Members by IBD-Associated Triggers in Intestinal Epithelial Cells, Their Correlation to Inflammation and Relevance to IBD Pathogenesis.
Saiz-Gonzalo G, Hanrahan N, Rossini V, Singh R, Ahern M, Kelleher M, Hill S, O'Sullivan R, Fanning A, Walsh PT, Hussey S, Shanahan F, Nally K, O'Driscoll CM, Melgar S. Saiz-Gonzalo G, et al. Front Immunol. 2021 Jul 29;12:655960. doi: 10.3389/fimmu.2021.655960. eCollection 2021. Front Immunol. 2021. PMID: 34394073 Free PMC article.