Gao S - Search Results

1

Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study.

Zhou Z, Meng B, An J, Zhao F, Sun Y, Zeng D, Wang W, Gao S, Xia Y, Dun C, De Clercq E, Pannecouque C, Zhan P, Kang D, Liu X. Zhou Z, et al. Among authors: gao s. Int J Mol Sci. 2023 Jan 7;24(2):1215. doi: 10.3390/ijms24021215. Int J Mol Sci. 2023. PMID: 36674730 Free PMC article.

2

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.

Kang D, Ruiz FX, Sun Y, Feng D, Jing L, Wang Z, Zhang T, Gao S, Sun L, De Clercq E, Pannecouque C, Arnold E, Zhan P, Liu X. Kang D, et al. Among authors: gao s. J Med Chem. 2021 Apr 8;64(7):4239-4256. doi: 10.1021/acs.jmedchem.1c00268. Epub 2021 Mar 18. J Med Chem. 2021. PMID: 33734714 Free PMC article.

3

SARS-CoV-2 Entry Inhibitors Targeting Virus-ACE2 or Virus-TMPRSS2 Interactions.

Lin H, Cherukupalli S, Feng D, Gao S, Kang D, Zhan P, Liu X. Lin H, et al. Among authors: gao s. Curr Med Chem. 2022;29(4):682-699. doi: 10.2174/0929867328666210420103021. Curr Med Chem. 2022. PMID: 33881969

4

Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.

Fu Z, Zhang T, Zhou Z, Kang D, Sun L, Gao S, Cherukupalli S, De Clercq E, Pannecouque C, Liu X, Zhan P. Fu Z, et al. Among authors: gao s. Bioorg Med Chem. 2021 Jul 15;42:116239. doi: 10.1016/j.bmc.2021.116239. Epub 2021 May 28. Bioorg Med Chem. 2021. PMID: 34090079

5

Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors.

Gao S, Huang T, Song L, Xu S, Cheng Y, Cherukupalli S, Kang D, Zhao T, Sun L, Zhang J, Zhan P, Liu X. Gao S, et al. Acta Pharm Sin B. 2022 Feb;12(2):581-599. doi: 10.1016/j.apsb.2021.08.027. Epub 2021 Aug 31. Acta Pharm Sin B. 2022. PMID: 34485029 Free PMC article. Review.

6

Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP.

Zhang T, Zhou Z, Zalloum WA, Wang Z, Fu Z, Cherukupalli S, Feng D, Sun Y, Gao S, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Zhang T, et al. Among authors: gao s. Bioorg Chem. 2021 Nov;116:105353. doi: 10.1016/j.bioorg.2021.105353. Epub 2021 Sep 11. Bioorg Chem. 2021. PMID: 34536931

7

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

Xu S, Sun L, Dick A, Zalloum WA, Huang T, Meuser ME, Zhang X, Tao Y, Cherukupalli S, Ding D, Ding X, Gao S, Jiang X, Kang D, De Clercq E, Pannecouque C, Cocklin S, Liu X, Zhan P. Xu S, et al. Among authors: gao s. Eur J Med Chem. 2022 Jan 5;227:113903. doi: 10.1016/j.ejmech.2021.113903. Epub 2021 Oct 9. Eur J Med Chem. 2022. PMID: 34653770 Free PMC article.

8

Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors.

Xu S, Song S, Sun L, Gao P, Gao S, Ma Y, Kang D, Cheng Y, Zhang X, Cherukupalli S, De Clercq E, Pannecouque C, Liu X, Zhan P. Xu S, et al. Among authors: gao s, gao p. Bioorg Med Chem. 2022 Jan 1;53:116531. doi: 10.1016/j.bmc.2021.116531. Epub 2021 Dec 3. Bioorg Med Chem. 2022. PMID: 34890994

9

Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.

Kang D, Sun Y, Feng D, Gao S, Wang Z, Jing L, Zhang T, Jiang X, Lin H, De Clercq E, Pannecouque C, Zhan P, Liu X. Kang D, et al. Among authors: gao s. J Med Chem. 2022 Feb 10;65(3):2458-2470. doi: 10.1021/acs.jmedchem.1c01885. Epub 2022 Jan 21. J Med Chem. 2022. PMID: 35061384

10

Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features.

Gao S, Cheng Y, Song S, Song L, Zhao F, Xu S, Kang D, Sun L, Gao P, De Clercq E, Pannecouque C, Liu X, Zhan P. Gao S, et al. Among authors: gao p. Eur J Med Chem. 2022 Aug 5;238:114471. doi: 10.1016/j.ejmech.2022.114471. Epub 2022 May 20. Eur J Med Chem. 2022. PMID: 35640327

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