Rajan R - Search Results

1

Optimized protocols for the characterization of Cas12a activities.

Martin L, Rostami S, Rajan R. Martin L, et al. Among authors: rajan r. Methods Enzymol. 2023;679:97-129. doi: 10.1016/bs.mie.2022.08.048. Methods Enzymol. 2023. PMID: 36682874 Free PMC article.

2

Nucleic Acid-Dependent Conformational Changes in CRISPR-Cas9 Revealed by Site-Directed Spin Labeling.

Vazquez Reyes C, Tangprasertchai NS, Yogesha SD, Nguyen RH, Zhang X, Rajan R, Qin PZ. Vazquez Reyes C, et al. Among authors: rajan r. Cell Biochem Biophys. 2017 Jun;75(2):203-210. doi: 10.1007/s12013-016-0738-5. Epub 2016 Jun 24. Cell Biochem Biophys. 2017. PMID: 27342128 Free PMC article.

3

The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit.

Murugan K, Babu K, Sundaresan R, Rajan R, Sashital DG. Murugan K, et al. Among authors: rajan r. Mol Cell. 2017 Oct 5;68(1):15-25. doi: 10.1016/j.molcel.2017.09.007. Mol Cell. 2017. PMID: 28985502 Free PMC article. Review.

4

RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a.

Sundaresan R, Parameshwaran HP, Yogesha SD, Keilbarth MW, Rajan R. Sundaresan R, et al. Among authors: rajan r. Cell Rep. 2017 Dec 26;21(13):3728-3739. doi: 10.1016/j.celrep.2017.11.100. Cell Rep. 2017. PMID: 29281823 Free PMC article.

5

Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance.

Babu K, Amrani N, Jiang W, Yogesha SD, Nguyen R, Qin PZ, Rajan R. Babu K, et al. Among authors: rajan r. Biochemistry. 2019 Apr 9;58(14):1905-1917. doi: 10.1021/acs.biochem.8b01241. Epub 2019 Mar 27. Biochemistry. 2019. PMID: 30916546 Free PMC article.

6

Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain.

Zuo Z, Zolekar A, Babu K, Lin VJ, Hayatshahi HS, Rajan R, Wang YC, Liu J. Zuo Z, et al. Among authors: rajan r. Elife. 2019 Jul 30;8:e46500. doi: 10.7554/eLife.46500. Elife. 2019. PMID: 31361218 Free PMC article.

7

CRISPR type II-A subgroups exhibit phylogenetically distinct mechanisms for prespacer insertion.

Van Orden MJ, Newsom S, Rajan R. Van Orden MJ, et al. Among authors: rajan r. J Biol Chem. 2020 Aug 7;295(32):10956-10968. doi: 10.1074/jbc.RA120.013554. Epub 2020 Jun 8. J Biol Chem. 2020. PMID: 32513871 Free PMC article.

8

The bridge helix of Cas12a imparts selectivity in cis-DNA cleavage and regulates trans-DNA cleavage.

Parameshwaran HP, Babu K, Tran C, Guan K, Allen A, Kathiresan V, Qin PZ, Rajan R. Parameshwaran HP, et al. Among authors: rajan r. FEBS Lett. 2021 Apr;595(7):892-912. doi: 10.1002/1873-3468.14051. Epub 2021 Feb 28. FEBS Lett. 2021. PMID: 33523494 Free PMC article.

9

The CRISPR-Cas Mechanism for Adaptive Immunity and Alternate Bacterial Functions Fuels Diverse Biotechnologies.

Newsom S, Parameshwaran HP, Martin L, Rajan R. Newsom S, et al. Among authors: rajan r. Front Cell Infect Microbiol. 2021 Jan 28;10:619763. doi: 10.3389/fcimb.2020.619763. eCollection 2020. Front Cell Infect Microbiol. 2021. PMID: 33585286 Free PMC article. Review.

10

Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence.

Babu K, Kathiresan V, Kumari P, Newsom S, Parameshwaran HP, Chen X, Liu J, Qin PZ, Rajan R. Babu K, et al. Among authors: rajan r. Biochemistry. 2021 Dec 14;60(49):3783-3800. doi: 10.1021/acs.biochem.1c00354. Epub 2021 Nov 10. Biochemistry. 2021. PMID: 34757726 Free PMC article.

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