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Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity.
Zhang B, Sun J, Yuan Y, Ji D, Sun Y, Liu Y, Li S, Zhu X, Wu X, Hu J, Xie Q, Wu L, Liu L, Cheng B, Zhang Y, Jiang L, Zhao L, Yu F, Song W, Wang M, Xu Y, Ma S, Fei Y, Zhang L, Zhou D, Zhang X. Zhang B, et al. Among authors: cheng b. Signal Transduct Target Ther. 2023 Jan 23;8(1):28. doi: 10.1038/s41392-022-01208-3. Signal Transduct Target Ther. 2023. PMID: 36690610 Free PMC article.
Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells.
Zhang B, Sun J, Wang Y, Ji D, Yuan Y, Li S, Sun Y, Hou Y, Li P, Zhao L, Yu F, Ma W, Cheng B, Wu L, Hu J, Wang M, Song W, Li X, Li H, Fei Y, Chen H, Zhang L, Tsokos GC, Zhou D, Zhang X. Zhang B, et al. Among authors: cheng b. Nat Biomed Eng. 2021 Nov;5(11):1288-1305. doi: 10.1038/s41551-021-00797-8. Epub 2021 Sep 27. Nat Biomed Eng. 2021. PMID: 34580438
An engineered influenza virus to deliver antigens for lung cancer vaccination.
Ji D, Zhang Y, Sun J, Zhang B, Ma W, Cheng B, Wang X, Li Y, Mu Y, Xu H, Wang Q, Zhang C, Xiao S, Zhang L, Zhou D. Ji D, et al. Among authors: cheng b. Nat Biotechnol. 2024 Mar;42(3):518-528. doi: 10.1038/s41587-023-01796-7. Epub 2023 May 25. Nat Biotechnol. 2024. PMID: 37231262
5,241 results