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A universal deep-learning model for zinc finger design enables transcription factor reprogramming.
Ichikawa DM, Abdin O, Alerasool N, Kogenaru M, Mueller AL, Wen H, Giganti DO, Goldberg GW, Adams S, Spencer JM, Razavi R, Nim S, Zheng H, Gionco C, Clark FT, Strokach A, Hughes TR, Lionnet T, Taipale M, Kim PM, Noyes MB. Ichikawa DM, et al. Among authors: kim pm. Nat Biotechnol. 2023 Aug;41(8):1117-1129. doi: 10.1038/s41587-022-01624-4. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702896 Free PMC article.
C2H2 zinc finger proteins greatly expand the human regulatory lexicon.
Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. Najafabadi HS, et al. Among authors: kim pm. Nat Biotechnol. 2015 May;33(5):555-62. doi: 10.1038/nbt.3128. Epub 2015 Feb 18. Nat Biotechnol. 2015. PMID: 25690854
ELASPIC web-server: proteome-wide structure-based prediction of mutation effects on protein stability and binding affinity.
Witvliet DK, Strokach A, Giraldo-Forero AF, Teyra J, Colak R, Kim PM. Witvliet DK, et al. Among authors: kim pm. Bioinformatics. 2016 May 15;32(10):1589-91. doi: 10.1093/bioinformatics/btw031. Epub 2016 Jan 21. Bioinformatics. 2016. PMID: 26801957
AVAILABILITY AND IMPLEMENTATION: The ELASPIC webserver is available online at http://elaspic.kimlab.org CONTACT: pm.kim@utoronto.ca or pi@kimlab.orgSupplementary data: Supplementary data are available at Bioinformatics online....
AVAILABILITY AND IMPLEMENTATION: The ELASPIC webserver is available online at http://elaspic.kimlab.org CONTACT: pm.kim@utoron …
157 results