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A universal deep-learning model for zinc finger design enables transcription factor reprogramming.
Ichikawa DM, Abdin O, Alerasool N, Kogenaru M, Mueller AL, Wen H, Giganti DO, Goldberg GW, Adams S, Spencer JM, Razavi R, Nim S, Zheng H, Gionco C, Clark FT, Strokach A, Hughes TR, Lionnet T, Taipale M, Kim PM, Noyes MB. Ichikawa DM, et al. Among authors: noyes mb. Nat Biotechnol. 2023 Aug;41(8):1117-1129. doi: 10.1038/s41587-022-01624-4. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702896 Free PMC article.
Brain and cancer associated binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation.
Do C, Jiang G, Cova G, Katsifis CC, Narducci DN, Sakellaropoulos T, Vidal R, Lhoumaud P, Tsirigos A, Regis FFD, Kakabadze N, Nora EP, Noyes M, Hansen AS, Skok JA. Do C, et al. bioRxiv [Preprint]. 2024 Sep 25:2024.01.11.575070. doi: 10.1101/2024.01.11.575070. bioRxiv. 2024. PMID: 38370764 Free PMC article. Preprint.
33 results