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Platelet intrinsic apoptosis.
Josefsson EC. Josefsson EC. Thromb Res. 2023 Nov;231:206-213. doi: 10.1016/j.thromres.2022.11.024. Epub 2022 Dec 12. Thromb Res. 2023. PMID: 36739256 Free article. Review.
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.
Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT. Josefsson EC, et al. J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12. J Exp Med. 2011. PMID: 21911424 Free PMC article.
Platelet life span and apoptosis.
Josefsson EC, White MJ, Dowling MR, Kile BT. Josefsson EC, et al. Methods Mol Biol. 2012;788:59-71. doi: 10.1007/978-1-61779-307-3_5. Methods Mol Biol. 2012. PMID: 22130700
Regulation of platelet lifespan by apoptosis.
Lebois M, Josefsson EC. Lebois M, et al. Among authors: josefsson ec. Platelets. 2016 Sep;27(6):497-504. doi: 10.3109/09537104.2016.1161739. Epub 2016 Apr 21. Platelets. 2016. PMID: 27100842 Free article. Review.
Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.
Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC. Pleines I, et al. Among authors: josefsson ec. Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355. Epub 2018 May 21. Blood. 2018. PMID: 29784641 Free article.
Transgenic, inducible RNAi in megakaryocytes and platelets in mice.
Takiguchi M, James C, Josefsson EC, Carmichael CL, Premsrirut PK, Lowe SW, Hamilton JR, Huang DC, Kile BT, Dickins RA. Takiguchi M, et al. Among authors: josefsson ec. J Thromb Haemost. 2010 Dec;8(12):2751-6. doi: 10.1111/j.1538-7836.2010.04077.x. J Thromb Haemost. 2010. PMID: 21138522 Free PMC article.
BCL-2 is dispensable for thrombopoiesis and platelet survival.
Debrincat MA, Pleines I, Lebois M, Lane RM, Holmes ML, Corbin J, Vandenberg CJ, Alexander WS, Ng AP, Strasser A, Bouillet P, Sola-Visner M, Kile BT, Josefsson EC. Debrincat MA, et al. Among authors: josefsson ec. Cell Death Dis. 2015 Apr 16;6(4):e1721. doi: 10.1038/cddis.2015.97. Cell Death Dis. 2015. PMID: 25880088 Free PMC article.
52 results