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Page 1
The turning point of COVID-19 severity is associated with a unique circulating neutrophil gene signature.
Fuzo CA, Fraga-Silva TFC, Maruyama SR, Bastos VAF, Rogerio LA, Takamiya NT, da Silva-Neto PV, Pimentel VE, Toro DM, Pérez MM, de Carvalho JCS, Carmona-Garcia I, Oliveira CNS, Degiovani AM, Ostini FM, Constant LF, de Amorim AP, Vilar FC, Feitosa MR, Parra RS, da Rocha JJR, Feres O, Gaspar GG, Viana AL, Fernandes APM, Santos IKFM, Russo EMS, Cardoso CRB, Sorgi CA, Faccioli LH, Bonato VLD, Dias-Baruffi M; ImmunoCOVID study group. Fuzo CA, et al. Immunology. 2023 Jul;169(3):323-343. doi: 10.1111/imm.13631. Epub 2023 Mar 8. Immunology. 2023. PMID: 36740582 Free article.
sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity.
da Silva-Neto PV, de Carvalho JCS, Pimentel VE, Pérez MM, Toro DM, Fraga-Silva TFC, Fuzo CA, Oliveira CNS, Rodrigues LC, Argolo JGM, Carmona-Garcia I, Neto NT, Souza COS, Fernandes TM, Bastos VAF, Degiovani AM, Constant LF, Ostini FM, Feitosa MR, Parra RS, Vilar FC, Gaspar GG, da Rocha JJR, Feres O, Frantz FG, Gerlach RF, Maruyama SR, Russo EMS, Viana AL, Fernandes APM, Santos IKFM, Bonato VLD, Boechat AL, Malheiro A, Sadikot RT, Dias-Baruffi M, Cardoso CRB, Faccioli LH, Sorgi CA, On Behalf Of The Imunocovid Study Group. da Silva-Neto PV, et al. Viruses. 2021 Dec 15;13(12):2521. doi: 10.3390/v13122521. Viruses. 2021. PMID: 34960790 Free PMC article.
Matrix Metalloproteinases on Severe COVID-19 Lung Disease Pathogenesis: Cooperative Actions of MMP-8/MMP-2 Axis on Immune Response through HLA-G Shedding and Oxidative Stress.
da Silva-Neto PV, do Valle VB, Fuzo CA, Fernandes TM, Toro DM, Fraga-Silva TFC, Basile PA, de Carvalho JCS, Pimentel VE, Pérez MM, Oliveira CNS, Rodrigues LC, Bastos VAF, Tella SOC, Martins RB, Degiovani AM, Ostini FM, Feitosa MR, Parra RS, Vilar FC, Gaspar GG, Rocha JJRD, Feres O, Arruda E, Maruyama SR, Russo EMS, Viana AL, Santos IKFM, Bonato VLD, Cardoso CRB, Tanus-Santos JE, Donadi EA, Faccioli LH, Dias-Baruffi M, Fernandes APM, Gerlach RF, Sorgi CA, On Behalf Of The Immunocovid Study Group. da Silva-Neto PV, et al. Biomolecules. 2022 Apr 19;12(5):604. doi: 10.3390/biom12050604. Biomolecules. 2022. PMID: 35625532 Free PMC article.
Acetylcholine, Fatty Acids, and Lipid Mediators Are Linked to COVID-19 Severity.
Pérez MM, Pimentel VE, Fuzo CA, da Silva-Neto PV, Toro DM, Fraga-Silva TFC, Gardinassi LG, Oliveira CNS, Souza COS, Torre-Neto NT, de Carvalho JCS, De Leo TC, Nardini V, Feitosa MR, Parra RS, da Rocha JJR, Feres O, Vilar FC, Gaspar GG, Constant LF, Ostini FM, Degiovani AM, Amorim AP, Viana AL, Fernandes APM, Maruyama SR, Russo EMS, Santos IKFM, Bonato VLD, Cardoso CRB, Sorgi CA, Dias-Baruffi M, Faccioli LH; ImmunoCOVID Brazilian Research Consortium. Pérez MM, et al. J Immunol. 2022 Jul 15;209(2):250-261. doi: 10.4049/jimmunol.2200079. Epub 2022 Jun 29. J Immunol. 2022. PMID: 35768148
Celastrol: A lead compound that inhibits SARS-CoV-2 replication, the activity of viral and human cysteine proteases, and virus-induced IL-6 secretion.
Fuzo CA, Martins RB, Fraga-Silva TFC, Amstalden MK, Canassa De Leo T, Souza JP, Lima TM, Faccioli LH, Okamoto DN, Juliano MA, França SC, Juliano L, Bonato VLD, Arruda E, Dias-Baruffi M. Fuzo CA, et al. Drug Dev Res. 2022 Nov;83(7):1623-1640. doi: 10.1002/ddr.21982. Epub 2022 Aug 21. Drug Dev Res. 2022. PMID: 35989498 Free PMC article.
The Severity of COVID-19 Affects the Plasma Soluble Levels of the Immune Checkpoint HLA-G Molecule.
Cordeiro JFC, Fernandes TM, Toro DM, da Silva-Neto PV, Pimentel VE, Pérez MM, de Carvalho JCS, Fraga-Silva TFC, Oliveira CNS, Argolo JGM, Degiovani AM, Ostini FM, Puginna EF, da Silva JS, Santos IKFM, Bonato VLD, Cardoso CRB, Dias-Baruffi M, Faccioli LH, Donadi EA, Sorgi CA, Fernandes APM, On Behalf Of The Immunocovid Study Group. Cordeiro JFC, et al. Int J Mol Sci. 2022 Aug 27;23(17):9736. doi: 10.3390/ijms23179736. Int J Mol Sci. 2022. PMID: 36077133 Free PMC article.
The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity.
Siekman SL, Pongracz T, Wang W, Nouta J, Kremsner PG, da Silva-Neto PV, Esen M, Kreidenweiss A, Held J, Trapé ÁA, Fendel R, de Miranda Santos IKF, Wuhrer M; ImmunoCovid Consortium. Siekman SL, et al. Front Immunol. 2022 Oct 18;13:993354. doi: 10.3389/fimmu.2022.993354. eCollection 2022. Front Immunol. 2022. PMID: 36389824 Free PMC article.
Cell death induced by NLRP3-palmitate axis impairs pulmonary damage tolerance and aggravates immunopathology during obesity-tuberculosis comorbidity.
Palma Albornoz SP, Fraga-Silva TF, de Carvalho RV, Rodrigues TS, Gembre AF, de Oliveira RS, de Souza FM, Corrêa GF, Ramalho LN, Carlos D, de Almeida DC, Câmara NO, Zamboni DS, Takahashi VN, Sorgi CA, Faccioli LH, Medeiros AI, Costa DL, Bonato VL. Palma Albornoz SP, et al. J Pathol. 2023 Mar;259(3):291-303. doi: 10.1002/path.6041. Epub 2023 Jan 3. J Pathol. 2023. PMID: 36441400
The Interplay among Glucocorticoid Therapy, Platelet-Activating Factor and Endocannabinoid Release Influences the Inflammatory Response to COVID-19.
de Carvalho JCS, da Silva-Neto PV, Toro DM, Fuzo CA, Nardini V, Pimentel VE, Pérez MM, Fraga-Silva TFC, Oliveira CNS, Degiovani AM, Ostini FM, Feitosa MR, Parra RS, da Rocha JJR, Feres O, Vilar FC, Gaspar GG, Santos IKFM, Fernandes APM, Maruyama SR, Russo EMS, Bonato VLD, Cardoso CRB, Dias-Baruffi M, Faccioli LH, Sorgi CA, On Behalf Of The ImmunoCovid Study Group. de Carvalho JCS, et al. Among authors: fraga silva tfc. Viruses. 2023 Feb 19;15(2):573. doi: 10.3390/v15020573. Viruses. 2023. PMID: 36851787 Free PMC article.
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