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Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson's disease.
Sastre D, Zafar F, Torres CAM, Piper D, Kirik D, Sanders LH, Qi S, Schüle B. Sastre D, et al. Among authors: kirik d. bioRxiv [Preprint]. 2023 Jan 24:2023.01.24.525105. doi: 10.1101/2023.01.24.525105. bioRxiv. 2023. Update in: Sci Rep. 2023 Oct 18;13(1):17796. doi: 10.1038/s41598-023-45078-3 PMID: 36747875 Free PMC article. Updated. Preprint.
State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons.
Basso V, Döbrössy MD, Thompson LH, Kirik D, Fuller HR, Gates MA. Basso V, et al. Among authors: kirik d. Biology (Basel). 2024 Sep 3;13(9):690. doi: 10.3390/biology13090690. Biology (Basel). 2024. PMID: 39336117 Free PMC article. Review.
Aging, Parkinson's Disease, and Models: What Are the Challenges?
Rocha E, Chamoli M, Chinta SJ, Andersen JK, Wallis R, Bezard E, Goldberg M, Greenamyre T, Hirst W, Kuan WL, Kirik D, Niedernhofer L, Rappley I, Padmanabhan S, Trudeau LE, Spillantini M, Scott S, Studer L, Bellantuono I, Mortiboys H. Rocha E, et al. Among authors: kirik d. Aging Biol. 2023;1:e20230010. doi: 10.59368/agingbio.20230010. Epub 2023 Jul 28. Aging Biol. 2023. PMID: 38978807 Free PMC article.
Basal activity of PINK1 and PRKN in cell models and rodent brain.
Watzlawik JO, Fiesel FC, Fiorino G, Bustillos BA, Baninameh Z, Markham BN, Hou X, Hayes CS, Bredenberg JM, Kurchaba NW, Fričová D, Siuda J, Wszolek ZK, Noda S, Sato S, Hattori N, Prasad AA, Kirik D, Fox HS, Stauch KL, Goldberg MS, Springer W. Watzlawik JO, et al. Among authors: kirik d. Autophagy. 2024 May;20(5):1147-1158. doi: 10.1080/15548627.2023.2286414. Epub 2023 Dec 2. Autophagy. 2024. PMID: 38041584 Free PMC article.
183 results