George DL - Search Results

1

Common activities and predictive gene signature identified for genetic hypomorphs of TP53.

Leung JC, Leu JI, Indeglia A, Kannan T, Clarke NL, Kirven NA, Dweep H, Garlick D, Barnoud T, Kossenkov AV, George DL, Murphy ME. Leung JC, et al. Among authors: george dl. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212940120. doi: 10.1073/pnas.2212940120. Epub 2023 Feb 7. Proc Natl Acad Sci U S A. 2023. PMID: 36749725 Free PMC article.

2

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.

Leu JI, Murphy ME, George DL. Leu JI, et al. Among authors: george dl. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8390-8396. doi: 10.1073/pnas.1821277116. Epub 2019 Apr 8. Proc Natl Acad Sci U S A. 2019. PMID: 30962386 Free PMC article.

3

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.

Leu JI, Murphy ME, George DL. Leu JI, et al. Among authors: george dl. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26804-26811. doi: 10.1073/pnas.2009943117. Epub 2020 Oct 14. Proc Natl Acad Sci U S A. 2020. PMID: 33055209 Free PMC article.

4

Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria.

Leu JI, George DL. Leu JI, et al. Among authors: george dl. Genes Dev. 2007 Dec 1;21(23):3095-109. doi: 10.1101/gad.1567107. Genes Dev. 2007. PMID: 18056423 Free PMC article.

5

The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver.

Leu JI, Murphy ME, George DL. Leu JI, et al. Among authors: george dl. J Liver. 2013;2(1):117. doi: 10.4172/2167-0889.1000117. J Liver. 2013. PMID: 23991369 Free PMC article.

6

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction.

Kung CP, Leu JI, Basu S, Khaku S, Anokye-Danso F, Liu Q, George DL, Ahima RS, Murphy ME. Kung CP, et al. Among authors: george dl. Cell Rep. 2016 Mar 15;14(10):2413-25. doi: 10.1016/j.celrep.2016.02.037. Epub 2016 Mar 3. Cell Rep. 2016. PMID: 26947067 Free PMC article.

7

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model.

Jennis M, Kung CP, Basu S, Budina-Kolomets A, Leu JI, Khaku S, Scott JP, Cai KQ, Campbell MR, Porter DK, Wang X, Bell DA, Li X, Garlick DS, Liu Q, Hollstein M, George DL, Murphy ME. Jennis M, et al. Among authors: george dl. Genes Dev. 2016 Apr 15;30(8):918-30. doi: 10.1101/gad.275891.115. Epub 2016 Mar 31. Genes Dev. 2016. PMID: 27034505 Free PMC article.

8

Tailoring Chemotherapy for the African-Centric S47 Variant of TP53.

Barnoud T, Budina-Kolomets A, Basu S, Leu JI, Good M, Kung CP, Liu J, Liu Q, Villanueva J, Zhang R, George DL, Murphy ME. Barnoud T, et al. Among authors: george dl. Cancer Res. 2018 Oct 1;78(19):5694-5705. doi: 10.1158/0008-5472.CAN-18-1327. Epub 2018 Aug 16. Cancer Res. 2018. PMID: 30115697 Free PMC article.

9

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin.

Singh KS, Leu JI, Barnoud T, Vonteddu P, Gnanapradeepan K, Lin C, Liu Q, Barton JC, Kossenkov AV, George DL, Murphy ME, Dotiwala F. Singh KS, et al. Among authors: george dl. Nat Commun. 2020 Jan 24;11(1):473. doi: 10.1038/s41467-019-14151-9. Nat Commun. 2020. PMID: 31980600 Free PMC article.

10

Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser.

Gnanapradeepan K, Leu JI, Basu S, Barnoud T, Good M, Lee JV, Quinn WJ, Kung CP, Ahima R, Baur JA, Wellen KE, Liu Q, Schug ZT, George DL, Murphy ME. Gnanapradeepan K, et al. Among authors: george dl. Elife. 2020 Nov 10;9:e55994. doi: 10.7554/eLife.55994. Elife. 2020. PMID: 33170774 Free PMC article.

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