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Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models.
Parker S, McDowall C, Sanchez-Perez L, Osorio C, Duncker PC, Briley A, Swartz AM, Herndon JE 2nd, Yu YA, McLendon RE, Tedder TF, Desjardins A, Ashley DM, Gunn MD, Enterline DS, Knorr DA, Pastan IH, Nair SK, Bigner DD, Chandramohan V. Parker S, et al. Among authors: pastan ih. Sci Transl Med. 2023 Feb 8;15(682):eabn5649. doi: 10.1126/scitranslmed.abn5649. Epub 2023 Feb 8. Sci Transl Med. 2023. PMID: 36753564 Free PMC article.
Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.
Sampson JH, Akabani G, Archer GE, Bigner DD, Berger MS, Friedman AH, Friedman HS, Herndon JE 2nd, Kunwar S, Marcus S, McLendon RE, Paolino A, Penne K, Provenzale J, Quinn J, Reardon DA, Rich J, Stenzel T, Tourt-Uhlig S, Wikstrand C, Wong T, Williams R, Yuan F, Zalutsky MR, Pastan I. Sampson JH, et al. J Neurooncol. 2003 Oct;65(1):27-35. doi: 10.1023/a:1026290315809. J Neurooncol. 2003. PMID: 14649883 Clinical Trial.
Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.
Sampson JH, Brady ML, Petry NA, Croteau D, Friedman AH, Friedman HS, Wong T, Bigner DD, Pastan I, Puri RK, Pedain C. Sampson JH, et al. Neurosurgery. 2007 Feb;60(2 Suppl 1):ONS89-98; discussion ONS98-9. doi: 10.1227/01.NEU.0000249256.09289.5F. Neurosurgery. 2007. PMID: 17297371 Clinical Trial.
Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.
Sampson JH, Raghavan R, Brady ML, Provenzale JM, Herndon JE 2nd, Croteau D, Friedman AH, Reardon DA, Coleman RE, Wong T, Bigner DD, Pastan I, Rodríguez-Ponce MI, Tanner P, Puri R, Pedain C. Sampson JH, et al. Neuro Oncol. 2007 Jul;9(3):343-53. doi: 10.1215/15228517-2007-007. Epub 2007 Apr 13. Neuro Oncol. 2007. PMID: 17435179 Free PMC article. Clinical Trial.
Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.
Sampson JH, Akabani G, Archer GE, Berger MS, Coleman RE, Friedman AH, Friedman HS, Greer K, Herndon JE 2nd, Kunwar S, McLendon RE, Paolino A, Petry NA, Provenzale JM, Reardon DA, Wong TZ, Zalutsky MR, Pastan I, Bigner DD. Sampson JH, et al. Neuro Oncol. 2008 Jun;10(3):320-9. doi: 10.1215/15228517-2008-012. Epub 2008 Apr 10. Neuro Oncol. 2008. PMID: 18403491 Free PMC article. Clinical Trial.
310 results