Parker JA - Search Results

1

PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.

Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK. Hung ST, et al. Among authors: parker ja. Cell. 2023 Feb 16;186(4):786-802.e28. doi: 10.1016/j.cell.2023.01.005. Epub 2023 Feb 7. Cell. 2023. PMID: 36754049 Free PMC article.

2

Genetic and pharmacological PARP inhibition reduces axonal degeneration in C. elegans models of ALS.

Tossing G, Livernoche R, Maios C, Bretonneau C, Labarre A, Parker JA. Tossing G, et al. Among authors: parker ja. Hum Mol Genet. 2022 Sep 29;31(19):3313-3324. doi: 10.1093/hmg/ddac116. Hum Mol Genet. 2022. PMID: 35594544

3

Small Molecule Rescue of ATXN3 Toxicity in C. elegans via TFEB/HLH-30.

Fardghassemi Y, Maios C, Parker JA. Fardghassemi Y, et al. Among authors: parker ja. Neurotherapeutics. 2021 Apr;18(2):1151-1165. doi: 10.1007/s13311-020-00993-5. Epub 2021 Mar 29. Neurotherapeutics. 2021. PMID: 33782863 Free PMC article.

4

A single copy transgenic mutant FUS strain reproduces age-dependent ALS phenotypes in C. elegans.

Labarre A, Tossing G, Maios C, Doyle JJ, Parker JA. Labarre A, et al. Among authors: parker ja. MicroPubl Biol. 2021 Sep 22;2021:10.17912/micropub.biology.000473. doi: 10.17912/micropub.biology.000473. eCollection 2021. MicroPubl Biol. 2021. PMID: 34568776 Free PMC article.

5

Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.

Doyle JJ, Maios C, Vrancx C, Duhaime S, Chitramuthu B, Bennett HPJ, Bateman A, Parker JA. Doyle JJ, et al. Among authors: parker ja. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2022115118. doi: 10.1073/pnas.2022115118. Proc Natl Acad Sci U S A. 2021. PMID: 34140407 Free PMC article.

6

Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio.

Vaccaro A, Patten SA, Ciura S, Maios C, Therrien M, Drapeau P, Kabashi E, Parker JA. Vaccaro A, et al. Among authors: parker ja. PLoS One. 2012;7(7):e42117. doi: 10.1371/journal.pone.0042117. Epub 2012 Jul 27. PLoS One. 2012. PMID: 22848727 Free PMC article.

7

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.

Vaccaro A, Patten SA, Aggad D, Julien C, Maios C, Kabashi E, Drapeau P, Parker JA. Vaccaro A, et al. Among authors: parker ja. Neurobiol Dis. 2013 Jul;55:64-75. doi: 10.1016/j.nbd.2013.03.015. Epub 2013 Apr 5. Neurobiol Dis. 2013. PMID: 23567652

8

Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis.

Patten SA, Aggad D, Martinez J, Tremblay E, Petrillo J, Armstrong GA, La Fontaine A, Maios C, Liao M, Ciura S, Wen XY, Rafuse V, Ichida J, Zinman L, Julien JP, Kabashi E, Robitaille R, Korngut L, Parker JA, Drapeau P. Patten SA, et al. Among authors: parker ja. JCI Insight. 2017 Nov 16;2(22):e97152. doi: 10.1172/jci.insight.97152. eCollection 2017 Nov 16. JCI Insight. 2017. PMID: 29202456 Free PMC article. Clinical Trial.

9

The Novel Small Molecule TRVA242 Stabilizes Neuromuscular Junction Defects in Multiple Animal Models of Amyotrophic Lateral Sclerosis.

Bose P, Tremblay E, Maios C, Narasimhan V, Armstrong GAB, Liao M, Parker JA, Robitaille R, Wen XY, Barden C, Drapeau P. Bose P, et al. Among authors: parker ja. Neurotherapeutics. 2019 Oct;16(4):1149-1166. doi: 10.1007/s13311-019-00765-w. Neurotherapeutics. 2019. PMID: 31342410 Free PMC article.

10

Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditiselegans model of spinal muscular atrophy.

Doyle JJ, Vrancx C, Maios C, Labarre A, Patten SA, Parker JA. Doyle JJ, et al. Among authors: parker ja. Dis Model Mech. 2020 Dec 22;13(12):dmm041350. doi: 10.1242/dmm.041350. Dis Model Mech. 2020. PMID: 33106327 Free PMC article.

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