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Page 1
Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains.
Apjok G, Számel M, Christodoulou C, Seregi V, Vásárhelyi BM, Stirling T, Eszenyi B, Sári T, Vidovics F, Nagrand E, Kovács D, Szili P, Lantos II, Méhi O, Jangir PK, Herczeg R, Gálik B, Urbán P, Gyenesei A, Draskovits G, Nyerges Á, Fekete G, Bodai L, Zsindely N, Dénes B, Yosef I, Qimron U, Papp B, Pál C, Kintses B. Apjok G, et al. Among authors: szili p. Nat Microbiol. 2023 Mar;8(3):410-423. doi: 10.1038/s41564-023-01320-2. Epub 2023 Feb 9. Nat Microbiol. 2023. PMID: 36759752 Free PMC article.
Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance.
Nyerges Á, Csörgő B, Draskovits G, Kintses B, Szili P, Ferenc G, Révész T, Ari E, Nagy I, Bálint B, Vásárhelyi BM, Bihari P, Számel M, Balogh D, Papp H, Kalapis D, Papp B, Pál C. Nyerges Á, et al. Among authors: szili p. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5726-E5735. doi: 10.1073/pnas.1801646115. Epub 2018 Jun 5. Proc Natl Acad Sci U S A. 2018. PMID: 29871954 Free PMC article.
Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations.
Szili P, Draskovits G, Révész T, Bogár F, Balogh D, Martinek T, Daruka L, Spohn R, Vásárhelyi BM, Czikkely M, Kintses B, Grézal G, Ferenc G, Pál C, Nyerges Á. Szili P, et al. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00207-19. doi: 10.1128/AAC.00207-19. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31235632 Free PMC article.
Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity.
Fois B, Skok Ž, Tomašič T, Ilaš J, Zidar N, Zega A, Peterlin Mašič L, Szili P, Draskovits G, Nyerges Á, Pál C, Kikelj D. Fois B, et al. Among authors: szili p. ChemMedChem. 2020 Feb 5;15(3):265-269. doi: 10.1002/cmdc.201900607. Epub 2019 Dec 10. ChemMedChem. 2020. PMID: 31721445
Second-generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors.
Lamut A, Skok Ž, Barančoková M, Gutierrez LJ, Cruz CD, Tammela P, Draskovits G, Szili PÉ, Nyerges Á, Pál C, Molek P, Bratkovič T, Ilaš J, Zidar N, Zega A, Enriz RD, Kikelj D, Tomašič T. Lamut A, et al. Among authors: szili pe. Future Med Chem. 2020 Feb;12(4):277-297. doi: 10.4155/fmc-2019-0127. Epub 2020 Feb 11. Future Med Chem. 2020. PMID: 32043377
Rational design of balanced dual-targeting antibiotics with limited resistance.
Nyerges A, Tomašič T, Durcik M, Revesz T, Szili P, Draskovits G, Bogar F, Skok Ž, Zidar N, Ilaš J, Zega A, Kikelj D, Daruka L, Kintses B, Vasarhelyi B, Foldesi I, Kata D, Welin M, Kimbung R, Focht D, Mašič LP, Pal C. Nyerges A, et al. Among authors: szili p. PLoS Biol. 2020 Oct 5;18(10):e3000819. doi: 10.1371/journal.pbio.3000819. eCollection 2020 Oct. PLoS Biol. 2020. PMID: 33017402 Free PMC article.
Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation.
Durcik M, Skok Ž, Ilaš J, Zidar N, Zega A, Szili PÉ, Draskovits G, Révész T, Kikelj D, Nyerges A, Pál C, Mašič LP, Tomašič T. Durcik M, et al. Among authors: szili pe. Pharmaceutics. 2020 Dec 22;13(1):6. doi: 10.3390/pharmaceutics13010006. Pharmaceutics. 2020. PMID: 33374964 Free PMC article.
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.
Durcik M, Nyerges Á, Skok Ž, Skledar DG, Trontelj J, Zidar N, Ilaš J, Zega A, Cruz CD, Tammela P, Welin M, Kimbung YR, Focht D, Benek O, Révész T, Draskovits G, Szili PÉ, Daruka L, Pál C, Kikelj D, Mašič LP, Tomašič T. Durcik M, et al. Among authors: szili pe. Eur J Med Chem. 2021 Mar 5;213:113200. doi: 10.1016/j.ejmech.2021.113200. Epub 2021 Jan 22. Eur J Med Chem. 2021. PMID: 33524686
15 results