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The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information.
Morris JH, Soman K, Akbas RE, Zhou X, Smith B, Meng EC, Huang CC, Cerono G, Schenk G, Rizk-Jackson A, Harroud A, Sanders L, Costes SV, Bharat K, Chakraborty A, Pico AR, Mardirossian T, Keiser M, Tang A, Hardi J, Shi Y, Musen M, Israni S, Huang S, Rose PW, Nelson CA, Baranzini SE. Morris JH, et al. Among authors: keiser m. Bioinformatics. 2023 Feb 3;39(2):btad080. doi: 10.1093/bioinformatics/btad080. Bioinformatics. 2023. PMID: 36759942 Free PMC article.
Mild chronic perturbation of inhibition severely alters hippocampal function.
Sun MY, Ziolkowski L, Lambert P, Shu HJ, Keiser M, Rensing N, Warikoo N, Martinek M, Platnick C, Benz A, Bracamontes J, Akk G, Steinbach JH, Zorumski CF, Wong M, Mennerick S. Sun MY, et al. Among authors: keiser m. Sci Rep. 2019 Nov 11;9(1):16431. doi: 10.1038/s41598-019-52851-w. Sci Rep. 2019. PMID: 31712706 Free PMC article.
Systems pharmacology augments drug safety surveillance.
Lorberbaum T, Nasir M, Keiser MJ, Vilar S, Hripcsak G, Tatonetti NP. Lorberbaum T, et al. Among authors: keiser mj. Clin Pharmacol Ther. 2015 Feb;97(2):151-8. doi: 10.1002/cpt.2. Epub 2014 Dec 20. Clin Pharmacol Ther. 2015. PMID: 25670520 Free PMC article.
Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.
Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D. Bruni G, et al. Among authors: keiser mj. Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097. Epub 2016 May 30. Nat Chem Biol. 2016. PMID: 27239787 Free PMC article.
The presynaptic component of the serotonergic system is required for clozapine's efficacy.
Yadav PN, Abbas AI, Farrell MS, Setola V, Sciaky N, Huang XP, Kroeze WK, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL. Yadav PN, et al. Neuropsychopharmacology. 2011 Feb;36(3):638-51. doi: 10.1038/npp.2010.195. Epub 2010 Nov 3. Neuropsychopharmacology. 2011. PMID: 21048700 Free PMC article.
Prediction and validation of enzyme and transporter off-targets for metformin.
Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM. Yee SW, et al. Among authors: keiser mj. J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):463-75. doi: 10.1007/s10928-015-9436-y. Epub 2015 Sep 3. J Pharmacokinet Pharmacodyn. 2015. PMID: 26335661 Free PMC article.
145 results