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Page 1
Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding.
Lee OW, Rodrigues C, Lin SH, Luo W, Jones K, Brown DW, Zhou W, Karlins E, Khan SM, Baulande S, Raynal V, Surdez D, Reynaud S, Rubio RA, Zaidi S, Grossetête S, Ballet S, Lapouble E, Laurence V, Pierron G, Gaspar N, Corradini N, Marec-Bérard P, Rothman N, Dagnall CL, Burdett L, Manning M, Wyatt K, Yeager M, Chari R, Leisenring WM, Kulozik AE, Kriebel J, Meitinger T, Strauch K, Kirchner T, Dirksen U, Mirabello L, Tucker MA, Tirode F, Armstrong GT, Bhatia S, Robison LL, Yasui Y, Romero-Pérez L, Hartmann W, Metzler M, Diver WR, Lori A, Freedman ND, Hoover RN, Morton LM, Chanock SJ, Grünewald TGP, Delattre O, Machiela MJ. Lee OW, et al. Among authors: chari r. Am J Hum Genet. 2023 Mar 2;110(3):427-441. doi: 10.1016/j.ajhg.2023.01.017. Epub 2023 Feb 13. Am J Hum Genet. 2023. PMID: 36787739 Free PMC article.
Massively parallel reporter assays and variant scoring identified functional variants and target genes for melanoma loci and highlighted cell-type specificity.
Long E, Yin J, Funderburk KM, Xu M, Feng J, Kane A, Zhang T, Myers T, Golden A, Thakur R, Kong H, Jessop L, Kim EY, Jones K, Chari R, Machiela MJ, Yu K; Melanoma Meta-Analysis Consortium; Iles MM, Landi MT, Law MH, Chanock SJ, Brown KM, Choi J. Long E, et al. Among authors: chari r. Am J Hum Genet. 2022 Dec 1;109(12):2210-2229. doi: 10.1016/j.ajhg.2022.11.006. Epub 2022 Nov 23. Am J Hum Genet. 2022. PMID: 36423637 Free PMC article.
Context-Dependent Function of Long Noncoding RNA PURPL in Transcriptome Regulation during p53 Activation.
Hartford CCR, Shrestha RL, Pongor L, Zhao Y, Chen X, Fromont C, Chaudhary R, Li XL, Pasterczyk KR, Kumar R, Muys BR, Tsitsipatis D, Chari R, Gorospe M, Aladjem MI, Khan J, Basrai MA, Grammatikakis I, Lal A. Hartford CCR, et al. Among authors: chari r. Mol Cell Biol. 2022 Dec 15;42(12):e0028922. doi: 10.1128/mcb.00289-22. Epub 2022 Nov 7. Mol Cell Biol. 2022. PMID: 36342127 Free PMC article.
EWSR1's visual modalities are defined by its association with nucleic acids and RNA polymerase II.
Rajan SS, Ebegboni VJ, Pichling P, Ludwig KR, Jones TL, Chari R, Tran A, Kruhlak MJ, Loncarek J, Caplen NJ. Rajan SS, et al. Among authors: chari r. bioRxiv [Preprint]. 2023 Aug 16:2023.08.16.553246. doi: 10.1101/2023.08.16.553246. bioRxiv. 2023. Update in: Mol Cell Biol. 2024;44(3):103-122. doi: 10.1080/10985549.2024.2315425 PMID: 37645932 Free PMC article. Updated. Preprint.
Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targe6ng of WRN and ATR.
Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A. Zong D, et al. Among authors: chari r. bioRxiv [Preprint]. 2023 Jul 30:2023.07.28.550976. doi: 10.1101/2023.07.28.550976. bioRxiv. 2023. Update in: Genes Dev. 2023 Oct 1;37(19-20):913-928. doi: 10.1101/gad.351085.123 PMID: 37662356 Free PMC article. Updated. Preprint.
Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants.
Sahu S, Sullivan TL, Mitrophanov AY, Galloux M, Nousome D, Southon E, Caylor D, Mishra AP, Evans CN, Clapp ME, Burkett S, Malys T, Chari R, Biswas K, Sharan SK. Sahu S, et al. Among authors: chari r. PLoS Genet. 2023 Sep 15;19(9):e1010940. doi: 10.1371/journal.pgen.1010940. eCollection 2023 Sep. PLoS Genet. 2023. PMID: 37713444 Free PMC article.
Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B.
Muys BR, Shrestha RL, Anastasakis DG, Pongor L, Li XL, Grammatikakis I, Polash A, Chari R, Gorospe M, Harris CC, Aladjem MI, Basrai MA, Hafner M, Lal A. Muys BR, et al. Among authors: chari r. Cell Rep. 2023 Mar 28;42(3):112260. doi: 10.1016/j.celrep.2023.112260. Epub 2023 Mar 15. Cell Rep. 2023. PMID: 36924503 Free PMC article.
374 results