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Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging.
Yeh CY, Chini LCS, Davidson JW, Garcia GG, Gallagher MS, Freichels IT, Calubag MF, Rodgers AC, Green CL, Babygirija R, Sonsalla MM, Pak HH, Trautman M, Hacker TA, Miller RA, Simcox J, Lamming DW. Yeh CY, et al. Among authors: lamming dw. bioRxiv [Preprint]. 2024 Jan 9:2023.02.06.527311. doi: 10.1101/2023.02.06.527311. bioRxiv. 2024. Update in: Nat Aging. 2024 Dec;4(12):1760-1771. doi: 10.1038/s43587-024-00744-7 PMID: 36798157 Free PMC article. Updated. Preprint.
The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.
Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. Soliman MA, et al. Among authors: lamming dw. Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Sci Signal. 2014. PMID: 24550542 Free PMC article.
Rapalogs and mTOR inhibitors as anti-aging therapeutics.
Lamming DW, Ye L, Sabatini DM, Baur JA. Lamming DW, et al. J Clin Invest. 2013 Mar;123(3):980-9. doi: 10.1172/JCI64099. Epub 2013 Mar 1. J Clin Invest. 2013. PMID: 23454761 Free PMC article. Review.
Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Hubbard BP, et al. Among authors: lamming dw. Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097. Science. 2013. PMID: 23471411 Free PMC article.
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM. Yilmaz ÖH, et al. Among authors: lamming dw. Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163. Nature. 2012. PMID: 22722868 Free PMC article.
121 results