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MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state.
You SF, Brase L, Filipello F, Iyer AK, Del-Aguila J, He J, D'Oliveira Albanus R, Budde J, Norton J, Gentsch J, Dräger NM, Sattler SM, Kampmann M, Piccio L, Morris JC, Perrin RJ, McDade E; Dominantly Inherited Alzheimer Network; Paul SM, Cashikar AG, Benitez BA, Harari O, Karch CM. You SF, et al. medRxiv [Preprint]. 2023 Feb 8:2023.02.06.23285545. doi: 10.1101/2023.02.06.23285545. medRxiv. 2023. PMID: 36798226 Free PMC article. Preprint.
Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers.
Brase L, You SF, D'Oliveira Albanus R, Del-Aguila JL, Dai Y, Novotny BC, Soriano-Tarraga C, Dykstra T, Fernandez MV, Budde JP, Bergmann K, Morris JC, Bateman RJ, Perrin RJ, McDade E, Xiong C, Goate AM, Farlow M; Dominantly Inherited Alzheimer Network (DIAN); Sutherland GT, Kipnis J, Karch CM, Benitez BA, Harari O. Brase L, et al. Among authors: you sf. Nat Commun. 2023 Apr 21;14(1):2314. doi: 10.1038/s41467-023-37437-5. Nat Commun. 2023. PMID: 37085492 Free PMC article.
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, Cantoni C, De Feo L, Ghezzi L, Minaya MA, Renganathan A, Cashikar AG, Satoh JI, Beatty W, Iyer AK, Cella M, Raskind WH, Piccio L, Karch CM. Filipello F, et al. Among authors: you sf. Acta Neuropathol. 2023 Jun;145(6):749-772. doi: 10.1007/s00401-023-02568-y. Epub 2023 Apr 28. Acta Neuropathol. 2023. PMID: 37115208 Free PMC article.
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia.
Iyer AK, Vermunt L, Mirfakhar FS, Minaya M, Acquarone M, Koppisetti RK, Renganathan A, You SF, Danhash EP, Verbeck A, Galasso G, Lee SM, Marsh J, Nana AL, Spina S, Seeley WW, Grinberg LT, Temple S, Teunissen CE, Sato C, Karch CM. Iyer AK, et al. Among authors: you sf. medRxiv [Preprint]. 2024 May 16:2024.05.15.24307444. doi: 10.1101/2024.05.15.24307444. medRxiv. 2024. PMID: 38798451 Free PMC article. Preprint.
19 results